Name: | Atenolol |
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PubChem Compound ID: | 175540 |
Description: | A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect. |
Molecular formula: | C14H22N2O3 |
Molecular weight: | 266.336 g/mol |
Synonyms: |
(S)-4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneacetamide; S-Atenolol; CAS-56715-13-0; (-)-Atenolol; EU-0100156; Lopac-A-7655; Tocris-0393; S-(-)-4-(2-Hydroxy-3-isopropylaminopropoxy)phenylacetamide; NCGC00015007-02; NCGC00015007-01.
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Name: | Atenolol |
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Name (isomeric): | DB00335 |
Drug Type: | small molecule |
Description: | A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect. |
Brand: | Aterol, Atenolin, Juvental, Atenol PB, Serten, Atenol Cophar, Atehexal, Atenol Gador, Uniloc, Atenol NM Pharma, Lotenal, Atcardil, Wesipin, Vericordin, Anselol, Tenolol, Betablok, Tenormin, Normalol, Atenet, Jenatenol, Duratenol, Atenol Trom, Stermin, Ateni, Corotenol, Premorine, Atenol Heumann, Evitocor, Hipres, Tensimin, Alinor, Atenol Quesada, Ormidol, Atenol MSD, Tenidon, Atenol Nordic, Atenol 1A Pharma, Tredol, Atenomel, Atenol-Ratiopharm, Scheinpharm Atenol, Altol, Betasyn, Aircrit, Atenblock, Atenol Fecofar, Blocotenol, Oraday, Prenormine, Blokium, Noten, Atenol-Wolff, Atecard, Tenobloc, Atenol Stada, Betatop GE, Normiten, Atenil, Loten, Atenol Genericon, Internolol, Atenol AL, Farnormin, Vascoten, Lo-Ten, Cuxanorm, Panapres, Atenol Von CT, Plenacor, Atenol Acis, Servitenol, Apo-Atenolol, Hypoten, Cardiopress, Teno-Basan, Seles Beta, Xaten, Selobloc, Atereal, Myocord, Cardaxen, Antipressan, Prenolol, Atenol CT, Tenoprin, Betacard, Ibinolo, Atenol Atid, Duraatenolol, Tenormine, Atenol-Mepha, Atenol Tika, Atendol, Felo-Bits, Unibloc, Tenoblock, Atenol, Prinorm, Atenol GNR |
Brand name mixture: | Tenoretic(atenolol + chlorthalidone) |
Category: | Sympatholytics, Adrenergic Agents, Antiarrhythmic Agents, Adrenergic beta-Antagonists, Anti-Arrhythmia Agents, Antihypertensive Agents |
CAS number: | 29122-68-7 |
Indication: | For the management of hypertention and long-term management of patients with angina pectoris |
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Pharmacology: |
Atenolol, a competitive beta(1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. Although it is similar to metoprolol, atenolol differs from pindolol and propranolol in that it does not have intrinsic sympathomimetic properties or membrane-stabilizing activity. Atenolol is used alone or with chlorthalidone in the...
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Mechanism of Action: |
Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hyp...
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Absorption: | Approximately 50% of an oral dose is absorbed from the gastrointestinal tract, the remainder being excreted unchanged in the feces. |
Protein binding: | Plasma protein binding is 6-16% |
Biotransformation: | Hepatic (minimal) |
Route of elimination: | Approximately 50% of an oral dose is absorbed from the gastrointestinal tract, the remainder being excreted unchanged in the feces. Unlike propranolol or metoprolol, but like nadolol, atenolol undergoes little or no metabolism by the liver, and the absorbed portion is eliminated primarily by renal excretion. |
Half Life: | 6-7 hours |
Toxicity: | LD50=2000-3000 mg/kg(orally in mice). Symptoms of an atenolol overdose include a slow heart beat, shortness of breath, fainting, dizziness, weakness, confusion, nausea, and vomiting. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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