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QuickView for Cloxacillin (compound)

Name: Cloxacillin
PubChem Compound ID: 1548956
Description: A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.
Molecular formula: C19H17ClN3O5S-
Molecular weight: 434.874 g/mol
Name: Cloxacillin
Name (isomeric): DB01147
Drug Type: small molecule
Description: A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.
Cloxacillin Sodium
Brand: Nu-Cloxi, Novo-Cloxin
Category: Anti-Bacterial Agents, Penicillins
CAS number: 61-72-3
Indication: Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.
Pharmacology: Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is for use against staphylococci that produce beta-lactamase.
Mechanism of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cloxacillin interferes with an autolysin inhibitor.
Absorption: Well absorbed from the gastrointestinal tract.
Protein binding: 95%
Toxicity: Oral LD50 in rat and mouse is 5000 mg/kg. Intravenous LD50 in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.
Affected organisms: Enteric bacteria and other eubacteria
Food interaction:
Take on an empty stomach.
Drug interaction:
OxytetracyclinePossible antagonism of action
Ethinyl EstradiolThis anti-infectious agent could decrease the effect of the oral contraceptive
MethacyclinePossible antagonism of action
DoxycyclinePossible antagonism of action
DemeclocyclinePossible antagonism of action
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