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QuickView for Furosemide (compound)

Name: Furosemide
PubChem Compound ID: 3440
Description: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
Molecular formula: C12H11ClN2O5S
Molecular weight: 330.745 g/mol
54-31-9; Furantril; Furosemide mita; Logirene; Benzoic acid, 5- (aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]-; Furosifar; Zafimida; Hoe-058A; Nicorol; Kutrix.
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Name: Furosemide
Name (isomeric): DB00695
Drug Type: small molecule
Description: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
Metflorylthiazidine; Fursemid; Fursemide; Furosemidu [Polish]; Furosemida [INN-Spanish]; Furosemidum [INN-Latin]; Methforylthiazidine; Fursemida; Frusemide; Dihydroflumethiazide.
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Brand: Uremide, Furocot, Diucardin, Frusid, Radisemide, Furesis, Depix, Golan, Hydol, Aquarid, Sigasalur, Desal, Furoter, Katlex, Furanthril, Lowpstron, Fursol, Logirene, Lowpston, Lasix, Jenafusid, Anfuramaide, Dirine, Furmid, Synephron, Rosemide, Seguril, Hydroled, Hydrex, Frusetic, Sal Diureticum, Novosemide, Urex-M, Furo-Puren, Oedemex, Promedes, Olmagran, Myrosemide, Nadis, Fulsix, Lasix Retard, Endural, Furodiurol, Impugan, Furose, Beronald, Diuzol, Furobeta, Lasemid, Diumide-K, Less Diur, Furo-Basan, Eutensin, Frumex, Furomide M.D., Apo-Frusemide, Hissuflux, Furoside, Diurolasa, Prefemin, Diusemide, Bristab, Furodrix, Neo-Renal, Rodiuran, Protargen, Edemid, Bioretic, Furosix, Arasemide, Promide, Transit, Aisemide, Lazix, Furex, Elodrine, Cetasix, Yidoli, Salurid, Frumide, Furanthryl, Urian, Furosan, Disal, Leodrine, Furosemix, Dryptal, Hydrenox, Mirfat, Durafurid, Aquasin, Uresix, Salurex, Diurapid, Errolon, Diuretic Salt, Furorese, Rosis, Polysquall A, Furosedon, Profemin, Macasirool, Apo-Furosemide, Disemide, Lasix Special, Vergonil, Hydro-Rapid, Fusid, Furovite, Vesix, Radouna, Lasex, Frusema, Furetic, Puresis, Marsemide, Lasiletten, Edenol, Hydro, Radonna, Sisuril, Saluron, Fuluvamine, Octan Draselny, Discoid, Desdemin, Fuluvamide, Urosemide, Odemase, Rusyde, Finuret, Eliur, Trofurit, Di-Ademil, Liside, Kofuzon, Aldalix, Selectofur, Furosifar, Nelsix, Dranex, Diural, Aluzine, Odemex, Frusemin, Laxur, Fluss, Furantril, Uridon, Bristurin, Kutrix, Fluidrol, Furfan, Aldic, Frumil, Zafimida, Moilarorin, Spirofur, Retep, Salix, Luscek, Urex, Farsix, Furomex, Mita, Furanturil, Kolkin, Rontyl, Furix, Diusil, Franyl, Salinex, Frusenex, Lasilix, Uritol, Diurin, Furomen, Frusedan
Category: Diuretics, Sodium Potassium Chloride Symporter Inhibitors
CAS number: 54-31-9
Indication: For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.
Pharmacology: Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.
Mechanism of Action:
Furosemide, a loop diuretic, inhibits water reabsorption in the nephron by blocking the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. This is achieved through competitive inhibition at the chloride binding site on the cotransporter, thus preventing the transport of sodium from the lumen of the loo...
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Absorption: 60% absorbed in patients with normal renal function
Protein binding: 95% bound to plasma proteins
Biotransformation: Only a small amount is hepatically metabolized to the defurfurylated derivative, 4-chloro-5-sulfamoylanthranilic acid.
Route of elimination: Furosemide is excreted in urine. Significantly more furosemide is excreted in urine following the I.V. injection than after the tablet or oral solution.
Half Life: 2 hours
Toxicity: Profound diuresis may cause fluid and electrolyte depletion. Excessive dehydration and potassium depletion may occur. Excessive diuresis may cause rapid weight loss, orthostatic hypotension or acute hypotensive episodes. May also cause tinnitus, reversible or permanent hearing loss or reversible deafness.
Affected organisms: Humans and other mammals
Food interaction:
Avoid alcohol.
Take with food to reduce irritation.
Increase potassium intake; add a banana or orange juice; unless instructed otherwise.
Avoid excess salt/sodium unless otherwise instructed by your physician.
Drug interaction:
DigitoxinPossible electrolyte variations and arrhythmias
IndomethacinThe NSAID, indomethacin, may decrease the diuretic and antihypertensive effects of the loop diuretic, furosemide.
KanamycinIncreased ototoxicity
ColesevelamBile acid sequestrants such as colesevelam may decrease the absorption of loop diuretics such as furosemide. Monitor for decreased serum concentrations/therapeutic effects of loop diuretics if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
DigoxinPossible electrolyte variations and arrhythmias
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