Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for Hydrochlorothiazide (compound)


PubChem
Name: Hydrochlorothiazide
PubChem Compound ID: 3639
Description: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
Molecular formula: C7H8ClN3O4S2
Molecular weight: 297.741 g/mol
Synonyms:
Dichlorosal; Hidril; component of Hydropres; Concor Plus; CAS-58-93-5; Unazid; Hydro-Diuril; Chlorsulfonamidodihydrobenzothiadiazine dioxide; SPBio_001259; NCGC00015508-01.
show more »
DrugBank
Identification
Name: Hydrochlorothiazide
Name (isomeric): DB00999
Drug Type: small molecule
Description: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
Synonyms:
HCTZ; Dihydrochlorurit; Dihydrochlorothiazid; Dihydrochlorothiazide; Dihydrochlorothiazidum; Hydrochlorothiazid; Dihydroxychlorothiazidum; Hydrochlorthiazide; Dihydrochlorurite; HCZ
Brand: Thlaretic, Hydro-Aquil, Neo-Codema, Chlorzide, Apresazide, Dichlotride, Hypothiazid, Diu-Melusin, Dichlorotride, Dichlorosal, Neoflumen, Dicyclotride, Esidrex, Aquarius, Vetidrex, Jen-Diril, Drenol, Nefrix, Thiuretic, Hidrotiazida, Caplaril, Hidril, Capozide, Microzide, Hydrodiuretic, Diclotride, Hydril, Esimil, Maschitt, Aquarills, Ivaugan, Megadiuril, Thiaretic, Fluvin, Newtolide, Ro-Hydrazide, Idrotiazide, Urodiazin, Hydrothide, HydroDIURIL, Direma, Bremil, Hidroronol, Hidrochlortiazid, Chlorosulthiadil, Disalunil, Hydrozide, Hydropres, Servithiazid, Hydrosaluric, Hypothiazide, Panurin, Timolide, Cidrex, Dichlotiazid
Brand name mixture:
Vaseretic(enalapril + hydrochlorothiazide), Timolide(timolol + hydrochlorothiazide), Zestoretic(lisinopril + hydrochlorothiazide), Dyazide(triamterene + hydrochlorothiazide), Uniretic HCT(moexipril + hydrochlorothiazide), Atacand HCT(candesartan + hydrochlorothiazide), Monopril-HCT(fosinopril + hydrochlorothiazide), Accuretic(quinapril + hydroc...
show more »
Category: Sodium Chloride Symporter Inhibitors, Diuretics, Antihypertensive Agents
CAS number: 58-93-5
Pharmacology
Indication: For the treatment of high blood pressure and management of edema.
Pharmacology:
Thiazides such as hydrochlorothiazide promote water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are no...
show more »
Mechanism of Action:
Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. Normally, the sodium-chloride symporter transports sodium and chloride from the lumen into the epithelial cell lining th...
show more »
Absorption: 50-60%
Protein binding: 67.9%
Biotransformation: Hydrochlorothiazide is not metabolized.
Route of elimination: Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney. Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.
Half Life: 5.6 and 14.8 hours
Toxicity: The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. The oral LD50 of hydrochlorothiazide is greater than 10 g/kg in the mouse and rat.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid alcohol.
Increase potassium intake; add a banana or orange juice; unless instructed otherwise.
Avoid excess salt/sodium unless otherwise instructed by your physician.
Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.
Avoid natural licorice.
show more »
Drug interaction:
DigitoxinPossible electrolyte variations and arrhythmias
DeslanosidePossible electrolyte variations and arrhythmias
DofetilideIncreased risk of cardiotoxicity and arrhythmias
TrandolaprilThe thiazide diuretic, Hydrochlorothiazide, may increase the hypotensive effect of Trandolapril. Hydrochlorothiazide may also increase the nephrotoxicity of Trandolapril. Monitor for postural hypotension at initiation of concomitant therapy and renal dysfunction during chronic therapy.
TenoxicamTenoxicam may antagonize the blood pressure lowering effect of Hydrochlorothiazide. Monitor for changes in the therapeutic effect of Hydrochlorothiazide if Tenoxicam is initiated, discontinued or dose changed.
show more »

Targets


Transporters