Name: | Dicloxacillin |
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PubChem Compound ID: | 1548960 |
Description: | One of the PENICILLINS which is resistant to PENICILLINASE. |
Molecular formula: | C19H17Cl2N3O5S |
Molecular weight: | 470.327 g/mol |
Name: | Dicloxacillin |
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Name (isomeric): | DB00485 |
Drug Type: | small molecule |
Description: | One of the PENICILLINS which is resistant to PENICILLINASE. |
Synonyms: |
Dicloxacillinum [INN-Latin]; Diclossacillina [DCIT]; Dicloxacillin Sodium; Dicloxacilline [INN-French]; Dicloxacilin; Dicloxacilina [INN-Spanish]; Dicloxacycline
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Brand: | Pathocil, Dycill, Maclicine, Dynapen |
Category: | Anti-Bacterial Agents, Penicillins |
CAS number: | 3116-76-5 |
Indication: | Used to treat infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug. |
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Pharmacology: |
Dicloxacillin is a beta-lactamase resistant penicillin similar to oxacillin. Dicloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of dicloxacillin results from the inhibition of cell wall synthesis and is mediated through dicloxacillin binding to penicillin bind...
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Mechanism of Action: |
Dicloxacillin exerts a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication. All penicillins inhibit the biosynthesis of the bacterial cell wall. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, dicloxacillin inhibits the third and last stage of ...
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Absorption: | Absorption of the isoxazolyl penicillins after oral administration is rapid but incomplete: peak blood levels are achieved in 1-1.5 hours. Oral absorption of cloxacillin, dicloxacillin, oxacillin and nafcillin is delayed when the drugs are administered after meals. |
Protein binding: | Binds to serum protein, mainly albumin. |
Route of elimination: | Dicloxacillin sodium is rapidly excreted as unchanged drug in the urine by glomerular filtration and active tubular secretion. |
Half Life: | The elimination half-life for dicloxacillin is about 0.7 hour. |
Toxicity: | Oral LD50 in rat is 3579 mg/kg. Symptoms of overexposure include irritation, rash, labored breathing, hives, itching, wheezing, nausea, chills, and fever. |
Affected organisms: | Enteric bacteria and other eubacteria |
Food interaction: |
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Drug interaction: |
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