Name: | Isosorbide Dinitrate |
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PubChem Compound ID: | 3780 |
Description: | A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action. |
Molecular formula: | C6H8N2O8 |
Molecular weight: | 236.136 g/mol |
Synonyms: |
Sorbonit; Tinidil; Iso-bid; Isorbid; Isordil Tembids; D-Glucitol, 1,4:3,6-dianhydro-, dinitrate; Vascardin; Isosorbide Dinitrate; Isordil; Isostat.
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Name: | Isosorbide Dinitrate |
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Name (isomeric): | DB00883 |
Drug Type: | small molecule |
Description: | A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action. |
Synonyms: |
Sorbidnitrate; Sorbide nitrate; Sorbide, dinitrate; Dianhydrosorbitol 2,5-dinitrate
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Brand: | Nitrosorbid, Vascardin, Iso-Bid, Isostat, Sorbislo, Maycor, Nosim, Lomilan, Resoidan, Difutrat, Isoket, ISDN, Isorbid, Isordil, Carvasin, Dinitrosorbide, Rigedal, Cardis, Sorbangil, Titradose, Nitrosorbide, Myorexon, Cardio 10, ISD, Xanyl, Isochron, Isotrate, Korodil, Dilatrate-SR, Tinidil, Ismotic, Sorbitrate, Sorbide T.D., Vasorbate, Harrical, Emoper, Sorquad, Cornilat, Corosorbide, Vasodilat, Dilatrate, Sorbidilat, Rifloc Retard, Coronex, Sorbonit, Nitrosorbon, IBD 20, Isordil Tembids, Flindix, Claodical, Carvanil, Cedocard |
Brand name mixture: | BiDil(isosorbide dinitrate + hydralazine hydrochloride) |
Category: | Nitrates and Nitrites, Vasodilator Agents, Nitric Oxide Donors |
CAS number: | 87-33-2 |
Indication: | For the prevention of angina pectoris due to coronary artery disease. |
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Pharmacology: |
Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return t...
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Mechanism of Action: |
Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dep...
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Absorption: | Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%. |
Protein binding: | Very low |
Biotransformation: | Hepatic |
Half Life: | 1 hour |
Toxicity: | Symptoms of overdose include reduced cardiac output and hypotension. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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