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QuickView for Isosorbide Dinitrate (compound)

Name: Isosorbide Dinitrate
PubChem Compound ID: 3780
Description: A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
Molecular formula: C6H8N2O8
Molecular weight: 236.136 g/mol
Sorbonit; Tinidil; Iso-bid; Isorbid; Isordil Tembids; D-Glucitol, 1,4:3,6-dianhydro-, dinitrate; Vascardin; Isosorbide Dinitrate; Isordil; Isostat.
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Name: Isosorbide Dinitrate
Name (isomeric): DB00883
Drug Type: small molecule
Description: A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
Sorbidnitrate; Sorbide nitrate; Sorbide, dinitrate; Dianhydrosorbitol 2,5-dinitrate
Brand: Nitrosorbid, Vascardin, Iso-Bid, Isostat, Sorbislo, Maycor, Nosim, Lomilan, Resoidan, Difutrat, Isoket, ISDN, Isorbid, Isordil, Carvasin, Dinitrosorbide, Rigedal, Cardis, Sorbangil, Titradose, Nitrosorbide, Myorexon, Cardio 10, ISD, Xanyl, Isochron, Isotrate, Korodil, Dilatrate-SR, Tinidil, Ismotic, Sorbitrate, Sorbide T.D., Vasorbate, Harrical, Emoper, Sorquad, Cornilat, Corosorbide, Vasodilat, Dilatrate, Sorbidilat, Rifloc Retard, Coronex, Sorbonit, Nitrosorbon, IBD 20, Isordil Tembids, Flindix, Claodical, Carvanil, Cedocard
Brand name mixture: BiDil(isosorbide dinitrate + hydralazine hydrochloride)
Category: Nitrates and Nitrites, Vasodilator Agents, Nitric Oxide Donors
CAS number: 87-33-2
Indication: For the prevention of angina pectoris due to coronary artery disease.
Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return t...
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Mechanism of Action:
Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dep...
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Absorption: Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.
Protein binding: Very low
Biotransformation: Hepatic
Half Life: 1 hour
Toxicity: Symptoms of overdose include reduced cardiac output and hypotension.
Affected organisms: Humans and other mammals
Food interaction:
Take without regard to meals. Absorption is faster on an empty stomach.
Drug interaction:
TelithromycinTelithromycin may reduce clearance of Isosorbide Dinitrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Isosorbide Dinitrate if Telithromycin is initiated, discontinued or dose changed.
SildenafilPossible significant hypotension with this combination
VoriconazoleVoriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of isosorbide dinitrate by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of isosorbide dinitrate if voriconazole is initiated, discontinued or dose changed.
DihydroergotaminePossible antagonism of action
TadalafilThe vasodilatory effects of Isosorbide dinitrate may be increased by Tadalafil. Severe hypotension may occur. Concomitant therapy is contraindicated.
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