QuickView for Methdilazine (compound)

10H-Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, monohydrochloride; NSC 169091; Tacaryl hydrochloride; CCRIS 6256; Methdilazine monohydrochloride; HSDB 5192; 1982-37-2; EINECS 214-967-3; Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, hydrochloride; 1229-35-2.
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10H-Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, monohydrochloride; NSC 169091; Tacaryl hydrochloride; CCRIS 6256; Methdilazine monohydrochloride; HSDB 5192; 1982-37-2; EINECS 214-967-3; Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, hydrochloride; 1229-35-2; Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, monohydrochloride; 10-((1-Methyl-3-pyrrolidinyl)methyl)phenothiazine, hydrochloride; Disyncran; 10-(1-Methyl-3-pyrroldiylmethyl)phenothiazine hydrochloride; 10-((1-Methyl-3-pyrrolidinyl)methyl)phenothiazine monohydrochloride; Bristaline; Dilosyn; MJ 5022; Methdilazine hydrochloride
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Methodilazine; Methdilazinum [INN-Latin]; Methdilazine Hcl; Methilazine hydrochloride; Metodilazina [INN-Spanish]; MD; Methdilazine Monohydrochloride; Methdilazine hydrochloride

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once rel...
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In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Methdilazine is a histamine H₁ antagonist. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
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