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QuickView for Methdilazine (compound)

Name: methdilazine
PubChem Compound ID: 14676
Molecular formula: C18H21ClN2S
Molecular weight: 332.892 g/mol
10H-Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, monohydrochloride; NSC 169091; Tacaryl hydrochloride; CCRIS 6256; Methdilazine monohydrochloride; HSDB 5192; 1982-37-2; EINECS 214-967-3; Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, hydrochloride; 1229-35-2.
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Name: methdilazine
Name (isomeric): DB00902
Drug Type: small molecule
Methodilazine; Methdilazinum [INN-Latin]; Methdilazine Hcl; Methilazine hydrochloride; Metodilazina [INN-Spanish]; MD; Methdilazine Monohydrochloride; Methdilazine hydrochloride
Brand: Tacazyl, Dilosyn, Bristaline, Disyncram, Tacryl, Disyncran, Tacaryl, Tacaryl hydrochloride
Category: Antihistamines
CAS number: 1982-37-2
Indication: Used for the symptomatic relief of hypersensitivity reactions and particularly for the control of pruritic skin disorders
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once rel...
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Mechanism of Action: Methdilazine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Absorption: Well absorbed in the digestive tract.
Toxicity: Symptoms of overdose include clumsiness or unsteadiness, convulsions, drowsiness, dryness of mouth, nose, or throat, feeling faint, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath or troubled breathing, shuffling walk, tic-like movements of head and face, trembling and shaking of hands, and trouble in sleeping.
Affected organisms: Humans and other mammals
Drug interaction:
BromocriptineThe phenothiazine decreases the effect of bromocriptine
FenfluramineDecreased anorexic effect, may increase psychotic symptoms
DonepezilPossible antagonism of action
TerfenadineIncreased risk of cardiotoxicity and arrhythmias
PhentermineDecreased anorexic effect, may increase psychotic symptoms
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