Name: | Phentermine |
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PubChem Compound ID: | 4771 |
Description: | A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity. |
Molecular formula: | C10H15N |
Molecular weight: | 149.233 g/mol |
Synonyms: |
Lonamin; alpha,alpha-Dimethylphenethylamine; Benzeneethanamine, .alpha.,.alpha.-dimethyl-; RCRA waste number P046; Benzeneethanamine, alpha,alpha-dimethyl-; 4-12-00-02820 (Beilstein Handbook Reference); Normephentermine; Phenethylamine, alpha,alpha-dimethyl-; Ortetamine; Fentermina [INN-Spanish].
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Name: | Phentermine |
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Name (isomeric): | DB00191 |
Drug Type: | small molecule |
Description: | A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity. |
Synonyms: |
(alpha,alpha)-Dimethylphenethylamine; Phentermine Hydrochloride; Phentermine Hcl
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Brand: | Phentercot, Wyamine Sulfate, Lonamin, Tora, Duromine, Mirapront, Ona Mast, Obenix, Fastin, Adipex-P, Normephentermine, Inoamin, Obestin-30, Phentermine Resin 30, Phentride, Wilpo, Pre-Sate, Uritone, Ona-Mast, Omnibex, Ionamin, Oby-Trim, Linyl, Pro-Fast, Teramine, Zantryl, Lipopill |
Brand name mixture: | Fen-phen(fenfluramine + phentermine) |
Category: | Anorexigenic Agents, Adrenergic Agents, Sympathomimetics, Appetite Depressants, Stimulants, Central Nervous System Stimulants, Central Nervous System Agents |
CAS number: | 122-09-8 |
Indication: | For the treatment and management of obesity. |
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Pharmacology: |
Phentermine is indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Phentermine hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central ...
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Mechanism of Action: |
Phentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. The drug seems to inhibit reuptake of noradrenaline, dopamine, and s...
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Absorption: | Phentermine is rapidly absorbed after oral ingestion. |
Protein binding: | Approximately 96.3% |
Biotransformation: | Hepatic. |
Half Life: | 16 to 31 hours |
Toxicity: | LD50 is adult monkeys is 15 to 20 mg/kg. Symptoms of overdose include delirium, mania, self-injury, marked hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, and circulatory collapse. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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