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QuickView for Phentermine (compound)


PubChem
Name: Phentermine
PubChem Compound ID: 4771
Description: A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
Molecular formula: C10H15N
Molecular weight: 149.233 g/mol
Synonyms:
Lonamin; alpha,alpha-Dimethylphenethylamine; Benzeneethanamine, .alpha.,.alpha.-dimethyl-; RCRA waste number P046; Benzeneethanamine, alpha,alpha-dimethyl-; 4-12-00-02820 (Beilstein Handbook Reference); Normephentermine; Phenethylamine, alpha,alpha-dimethyl-; Ortetamine; Fentermina [INN-Spanish].
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DrugBank
Identification
Name: Phentermine
Name (isomeric): DB00191
Drug Type: small molecule
Description: A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
Synonyms:
(alpha,alpha)-Dimethylphenethylamine; Phentermine Hydrochloride; Phentermine Hcl
Brand: Phentercot, Wyamine Sulfate, Lonamin, Tora, Duromine, Mirapront, Ona Mast, Obenix, Fastin, Adipex-P, Normephentermine, Inoamin, Obestin-30, Phentermine Resin 30, Phentride, Wilpo, Pre-Sate, Uritone, Ona-Mast, Omnibex, Ionamin, Oby-Trim, Linyl, Pro-Fast, Teramine, Zantryl, Lipopill
Brand name mixture: Fen-phen(fenfluramine + phentermine)
Category: Anorexigenic Agents, Adrenergic Agents, Sympathomimetics, Appetite Depressants, Stimulants, Central Nervous System Stimulants, Central Nervous System Agents
CAS number: 122-09-8
Pharmacology
Indication: For the treatment and management of obesity.
Pharmacology:
Phentermine is indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Phentermine hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central ...
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Mechanism of Action:
Phentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. The drug seems to inhibit reuptake of noradrenaline, dopamine, and s...
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Absorption: Phentermine is rapidly absorbed after oral ingestion.
Protein binding: Approximately 96.3%
Biotransformation: Hepatic.
Half Life: 16 to 31 hours
Toxicity: LD50 is adult monkeys is 15 to 20 mg/kg. Symptoms of overdose include delirium, mania, self-injury, marked hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, and circulatory collapse.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Limit caffeine intake.
Take without regard to meals.
Drug interaction:
MesoridazineDecreased anorexic effect, may increase psychotic symptoms
ChlorpromazineDecreased anorexic effect, may increase psychotic symptoms
TramadolIncreased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
MethdilazineDecreased anorexic effect, may increase psychotic symptoms
FluvoxamineRisk of serotoninergic syndrome
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