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QuickView for Dexfenfluramine (compound)
PubChem
| Name: | Dexfenfluramine |
|---|---|
| PubChem Compound ID: | 66264 |
| Description: | The S-isomer of FENFLURAMINE. It is a serotonin agonist and is used as an anorectic. Unlike fenfluramine, it does not possess any catecholamine agonist activity. |
| Molecular formula: | C12H17ClF3N |
| Molecular weight: | 267.718 g/mol |
| Synonyms: |
Dexfenfluramine hydrochloride [USAN]; DEA No. 1670; Dexafenfluramine hydrochloride; Redux (TN); Glypolix; IP-001; (+)-(S)-N-Ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochloride; Redux; (+)-Fenfluramine hydrochloride; EINECS 221-806-0.
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DrugBank
Identification
| Name: | Dexfenfluramine |
|---|---|
| Name (isomeric): | DB01191 |
| Drug Type: | small molecule |
| Description: | The S-isomer of FENFLURAMINE. It is a serotonin agonist and is used as an anorectic. Unlike fenfluramine, it does not possess any catecholamine agonist activity. |
| Synonyms: |
Dexfenfluraminum [Latin]; Dexfenfluramine Hydrochloride; Levofenfluramine [INN]; Levofenfluraminum [Latin]; D-Fenfluramine; Dexafenfluramine; Dexfenfluramina [Spanish]; Dextrofenfluramine; L-Fenfluramine; Levofenfluramina [Spanish].
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| Brand: | Redux, Adifax |
| Category: | Serotonin Agonists, Antiobesity Agents, Appetite Depressants, Serotonin reuptake inhibitor |
| CAS number: | 3239-44-9 |
Pharmacology
| Indication: | For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet |
|---|---|
| Pharmacology: | Used to treat diabetes and obesity, Dexfenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses. Dexfenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes. |
| Mechanism of Action: |
Dexfenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydr...
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| Absorption: | Well-absorbed from the gastrointestinal tract. |
| Protein binding: | 36% |
| Half Life: | 17-20 hours |
| Toxicity: | Symptoms of overdose include respiratory failure and cardiac arrest leading to death. |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
Enzymes
