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QuickView for Diethylpropion (compound)
PubChem
| Name: | Diethylpropion |
|---|---|
| PubChem Compound ID: | 7029 |
| Description: | A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290) |
| Molecular formula: | C13H19NO |
| Molecular weight: | 205.296 g/mol |
| Synonyms: |
Obesitex; Silutin; Neobes; Propiophenone, 2-(diethylamino)-; 2-(Diethylamino)-1-phenyl-1-propanone; Amphepramon; DEA No. 1610; alpha-Diethylaminopropiophenone; Adiposon; Dobesin.
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DrugBank
Identification
| Name: | Diethylpropion |
|---|---|
| Name (isomeric): | DB00937 |
| Drug Type: | small molecule |
| Description: | A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290) |
| Synonyms: |
Diethylcathinone; Amfepramone Hydrochloride; DEA No. 1610; alpha-Diethylaminopropiophenone; Amphepramonum hydrochloride; Diethylpropion HCL; Diethylpropione hydrochloride; Diethylpropion Hydrochloride; Anfepramona [INN-Spanish]; alpha-Benzoyltriethylamine.
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| Brand: | Tenuate, Amphepramone, Moderatan, Tenuate hydrochloride, Tepanil Ten-tab, Dobesin, Magrene, Frekentine, Regenon hydrochloride, Neobes, Nopropiophenone, Regenon, Keramik, Tylinal, Tenuate Dospan, Keramin, Tepanil, Modulor, Obesitex, Silutin, Anorex, Amfepramon, Derfon, Amfepramone, Adiposon, Danylen, Prefamone, Reginon, Anfamon, Parabolin, Cegramine, Amphepramon |
| Category: | Anorexigenic Agents, Appetite Depressants, Stimulants |
| CAS number: | 134-80-5 |
Pharmacology
| Indication: | Used in the management of exogenous obesity as a short-term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. |
|---|---|
| Pharmacology: | Diethylpropion is a sympathomimetic stimulant drug marketed as an appetite suppressant. Chemically, it is the N,N-diethyl analog of cathinone. Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine. |
| Mechanism of Action: |
Diethylpropion is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. Diethylpropion (through catecholamine elevation) may also indirec...
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| Absorption: | Diethylpropion is rapidly absorbed from the GI tract after oral administration. |
| Biotransformation: | Extensively metabolized through a complex pathway of biotransformation involving N-dealkylation and reduction. Many of these metabolites are biologically active and may participate in the therapeutic action of diethylpropion. |
| Route of elimination: | Diethylpropion is rapidly absorbed from the GI tract after oral administration and is extensively metabolized through a complex pathway of biotransformation involving N-dealkylation and reduction. Diethylpropion and/or its active metabolites are believed to cross the blood-brain barrier and the placenta. Diethylpropion and its metabolites are excreted mainly by the kidney. |
| Half Life: | Using a phosphorescence assay that is specific for basic compounds containing benzoyl group, the plasma half-life of the aminoketone metabolites is estimated to be between 4 to 6 hours. |
| Toxicity: | The reported oral LD50 for mice is 600 mg/kg, for rats is 250 mg/kg and for dogs is 225 mg/kg. Manifestation of acute overdosage include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, and panic states. |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
