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QuickView for Practolol (compound)
PubChem
| Name: | Practolol |
|---|---|
| PubChem Compound ID: | 10782613 |
| Description: | A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS. |
| Molecular formula: | C11H6Br2O2 |
| Molecular weight: | 329.972 g/mol |
DrugBank
Identification
| Name: | Practolol |
|---|---|
| Name (isomeric): | DB01297 |
| Drug Type: | small molecule |
| Description: | A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS. |
| Synonyms: |
Tocris-0831
|
| Category: | Adrenergic beta-Antagonists, Anti-Arrhythmia Agents |
| CAS number: | 6673-35-4 |
Pharmacology
| Indication: | Used in the emergency treatment of cardiac arrhythmias. |
|---|---|
| Pharmacology: |
Practolol is a beta-adrenergic receptor antagonist that has been used in the emergency treatment of cardiac arrhythmias. Beta blockers inhibit normal epinephrine-mediated sympathetic actions, but have minimal effect on resting subjects. That is, they reduce the effect of excitement/physical exertion on heart rate and force of contraction and dilat...
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| Mechanism of Action: |
Like other beta-adrenergic antagonists, practolol competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. Like propranolol and timolol, practolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects of the catecholamines epinephrine and norepinephr...
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| Toxicity: | Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing. |
Interactions
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Targets
