Name: | Metaproterenol |
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PubChem Compound ID: | 22167 |
Description: | A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM. |
Molecular formula: | C26H44N2O6S |
Molecular weight: | 512.703 g/mol |
Synonyms: |
Alupent; BENZYL ALCOHOL, 3,6-DIHYDROXY-alpha-((ISOPROPYLAMINO)METHYL)-, SULFATE (2:1) (sa; Metaprel; Benzyl alcohol, 3,5-dihydroxy-alpha-((isopropylamino)methyl)-, sulfate (2:1) (salt); 5874-97-5; Orciprenaline sulfate; 1,3-Benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, sulfate (2:1) (salt); Metaproterenol sulfate; Orciprenaline sulphate; Novasmasol.
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Name: | Metaproterenol |
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Name (isomeric): | DB00816 |
Drug Type: | small molecule |
Description: | A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM. |
Synonyms: |
Metaproterenol; Orciprenalina [INN-Spanish]; Orciprenalinum [INN-Latin]; Metaproterenol Sulfate; Orciprenaline Sulfate
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Brand: | Metaprel, Metaproterenol Polistirex, Alupent, Alotec, Prometa, Novasmasol |
Category: | Tocolytic Agents, Adrenergic beta-Agonists, Sympathomimetics, Bronchodilator Agents |
CAS number: | 586-06-1 |
Indication: | For the treatment of bronchospasm, chronic bronchitis, asthma, and emphysema. |
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Pharmacology: |
Orciprenaline (also known as metaproterenol), a synthetic amine, is structurally and pharmacologically similar to isoproterenol. Orciprenaline is used exclusively as a bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through beta adrenergic receptors ...
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Mechanism of Action: |
Orciprenaline is a moderately selective beta(2)-adrenergic agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. Intracellularly, the actions of orciprenaline are mediated by cAMP, the production of which is augmented by beta s...
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Absorption: | 3% (oral bioavailability of 40%) |
Biotransformation: | Hepatic and gastric. The major metabolite, orciprenaline-3-0-sulfate, is produced in the gastrointestinal tract. Orciprenaline is not metabolized by catechol-0-methyltransferase nor have glucuronide conjugates been isolated to date. |
Half Life: | 6 hours |
Toxicity: | Symptoms of overdose include angina, hypertension or hypotension, arrhythmias, nervousness, headache, tremor, dry mouth, palpitation, nausea, dizziness, fatigue, malaise and insomnia. LD50=42 mg/kg (orally in rat). |
Affected organisms: | Humans and other mammals |
Food interaction: |
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Drug interaction: |
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