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QuickView for Vilazodone (compound)

Name: vilazodone
PubChem Compound ID: 6918313
Molecular formula: C26H28ClN5O2
Molecular weight: 477.986 g/mol
SB-659746A; EMD-68843; Vilazodone hydrochloride
Name: vilazodone
Name (isomeric): DB06684
Drug Type: small molecule
SB 659746A
Category: Serotonin Agonists, Antidepressants, Selective Serotonin Reuptake Inhibitors (SSRIs)
Indication: Vilazodone is approved for treatment of acute episodes of major depression. Labeling of vilazodone describes an increased risk of suicidal thoughts in children, adolescents and young adults. The use of vilazodone in pediactrics is not indicated. Its use with monoamine oxidase inhibitors (MAOI) is contraindicated due to increased risk of serotonin syndome. Once the MAOI is discontinued, a 14-day washout period must pass before starting vilazodone.
Vilazodone increases serotonin levels in the brain by inhibiting the reuptake of serotonin while acting as a partial agonist on serotonin-1A receptors. It has therefore been coined by scientists as a selective partial agonist and reuptake inhibitor (SPARI). Because of its partial agonist activity for serotonin-1A, vilazodone helps to reduce anxiety...
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Mechanism of Action:
Since serotonin is believed to be one of the three main neurotransmitters that is low or imbalanced in patients with depression, pathways seeking to increase serotonin levels are targeted by pharmaceutical companies. As a selective serotonin reuptake inhibitor, vilazodone prevents serotonin from re-entering cell bodies. Hence, they will remain long...
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Absorption: Its absorption is improved when taken with food to 72%
Protein binding: 96-99% protein bound
  • Major: CYP3A4
  • Minor: CYP2C19 and CYP2D6
Route of elimination:
  • 1% recovered in urine
  • 2% unchanged in feces
Half Life: 25.4h
Clearance: 21.1L/h
Toxicity: Vomiting, serotonin syndrome
Food interaction:
Gingko bilboa, ginger, garlic, green tea, licorice, horseradish
Caution taking vilazodone with foods/herbal product with antiplatelet/anticoagulant properties
Drug interaction:
DextromethorphanConsideration should be given to avoiding the concomitant use of dextromethorphan and selective serotonin reuptake inhibitors (SSRI). Monitor for toxic effects of dextromethorphan (eg, CNS, Cardiovascular) if an SSRI is initiated or the dose is increased. SSRIs, other than fluoxetine and paroxetine, may be safer alternatives due to lesser CYP2D6 inhibition; however, the mechanism for the interaction is not fully understood, and caution is still advised.
MetoclopramideSeek alternatives to this combination when possible. Monitor patients receiving metoclopramide with selective serotonin reuptake inhibitors for signs of extrapyramidal symptoms, neuroleptic malignant syndrome, and serotonin syndrome.
LinezolidMAO Inhibitors may enhance the serotonergic effect of Selective Serotonin Reuptake Inhibitors. This may cause serotonin syndrome. Avoid combination.
ClarithromycinCYP3A4 Inhibitors (Strong) may increase the serum concentration of Vilazodone. imit maximum adult vilazodone dose to 20 mg/day in patients receiving strong CYP3A4 inhibitors.
CimetidineCimetidine may decrease the metabolism of Selective Serotonin Reuptake Inhibitors. Consider using an alternative H2-antagonist to avoid the risk of selective serotonin reuptake inhibitor (SSRI) toxicity. Monitor for increased therapeutic or toxic effects of SSRI if cimetidine is initiated/dose increased, or decreased effects if cimetidine is discontinued/dose decreased.
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