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QuickView for Naratriptan (compound)

Name: naratriptan
PubChem Compound ID: 10545065
Molecular formula: C17H25N3O2S
Molecular weight: 339.477 g/mol
Name: naratriptan
Name (isomeric): DB00952
Drug Type: small molecule
Brand: Naramig, Amerge
Category: Serotonin Agonists, Selective Serotonin Agonists, Vasoconstrictor Agents
CAS number: 121679-13-8
Indication: For the acute treatment of migraine attacks with or without aura in adults.
Naratriptan is a selective agonist of serotonin (5-hydroxytryptamine; 5-HT) type 1B and 1D receptors. It is structurally and pharmacologically related to other selective 5-HT1B/1D receptor agonist. Naratriptan has only a weak affinity for 5-HT1A, 5-HT5A, and 5-HT7 receptors and no significant affinity or pharmacolog...
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Mechanism of Action:
Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans: (1) stimulation of presynaptic 5-HT1D receptors, which serves to inhibit both dural vasodilation and inflammation; (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem and (3) vasoconstricti...
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Absorption: Well absorbed (74% oral biovaility), absorption is rapid with peak plasma concentrations after 2-5 hours. The rate of absorption is slower during a migraine attack.
Protein binding: 28%-31% (over the concentration range of 50 to 1000 ng/mL)
Biotransformation: Primarily hepatic. In vitro, naratriptan is metabolized by a wide range of cytochrome P450 isoenzymes into a number of inactive metabolites.
Half Life: 5-8 hours
Clearance: 6.6 mL/min/kg
Toxicity: Symptoms of overdose include light-headedness, loss of coordination, tension in the neck, and tiredness.
Affected organisms: Humans and other mammals
Food interaction:
Take without regard to meals.
Drug interaction:
FluvoxamineIncreased risk of CNS adverse effects
TramadolIncreased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
VilazodoneIncreased risk of serotonin syndrome
ErgonovinePossible severe and prolonged vasocontriction
TrimipramineIncreased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
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