Name: | Lorazepam |
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PubChem Compound ID: | 11609501 |
Description: | A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. |
Molecular formula: | C15H10Cl2N2O2 |
Molecular weight: | 324.136 g/mol |
Name: | Lorazepam |
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Name (isomeric): | DB00186 |
Drug Type: | small molecule |
Description: | A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. |
Synonyms: |
O-Chloroxazepam; (+/-)-Lorazepam; L-Lorazepam Acetate; O-Chlorooxazepam
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Brand: | Loraz, Wypax, Lorabenz, Quait, Pro Dorm, Aplacassee, Lorax, Almazine, Sedazin, Lorazepam Intensol, Sedatival, Psicopax, Idalprem, Securit, Temesta, Alzapam, Punktyl, Emotival, Delormetazepam, Somagerol, Tavor, Anxiedin, Bonatranquan, Lorsilan, Ativan |
Category: | Benzodiazepines, Anti-anxiety Agents, GABA Modulators, Hypnotics and Sedatives, Antiemetics, Anticonvulsants |
CAS number: | 846-49-1 |
Indication: | For the management of anxiety disorders, and for treatment of status epilepticus. |
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Pharmacology: | Lorazepam, a benzodiazepine not transformed to active metabolites, is used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia. |
Mechanism of Action: | Lorazepam binds to an allosteric site on GABA-A receptors, which are pentameric ionotropic receptors in the CNS. Binding potentiates the effects of the inhibitory neurotransmitter GABA, which upon binding opens the chloride channel in the receptor, allowing chloride influx and causing hyperpolerization of the neuron. |
Absorption: | Readily absorbed with an absolute bioavailability of 90%. |
Protein binding: | 85% |
Biotransformation: | Hepatic |
Route of elimination: | Lorazepam is rapidly conjugated at its 3-hydroxy group into lorazepam glucuronide which is then excreted in the urine. |
Half Life: | 12 hours |
Toxicity: | Somnolence, confusion, and coma, LD50=3178mg/kg (orally in mice). |
Affected organisms: | Humans and other mammals |
Food interaction: |
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