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QuickView for Acetophenazine (compound)

Name: acetophenazine
PubChem Compound ID: 17676
Molecular formula: C23H29N3O2S
Molecular weight: 411.561 g/mol
Ketone, 10-(3-(4-(2-hydroxyethyl-1-piperazinyl)propyl)phenothiazin-2-yl methyl; Acetophenazinum; 5714-00-1; Ethanone, 1-[10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl]-; 10-(3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl methyl ketone; Acetophenazine; 2751-68-0; Acephenazinum; Acetophenazina [INN-Spanish]; Acetophenazinum [INN-Latin].
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Name: acetophenazine
Name (isomeric): DB01063
Drug Type: small molecule
Brand: Tindal
Category: Antipsychotics
CAS number: 2751-68-0
Indication: For the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.)
Pharmacology: Acetophenzine is a phenothiazine antipsychotic intended for the management of schizophrenia and other psychotic disorders.
Mechanism of Action: Acetophenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Affected organisms: Humans and other mammals
Drug interaction:
TerfenadineIncreased risk of cardiotoxicity and arrhythmias
TrimethobenzamideTrimethobenzamide and Acetophenazine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
TetrabenazineMay cause dopamine deficiency. Monitor for Tetrabenazine adverse effects.
GuanethidineAcetophenazine may decrease the effect of guanethidine.
PhentermineDecreased anorexic effect, may increase psychotic symptoms
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