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QuickView for Almotriptan (compound)

Name: almotriptan
PubChem Compound ID: 123606
Molecular formula: C17H25N3O2S
Molecular weight: 335.465 g/mol
Almotriptan; KBio2_002408; Spectrum4_001134; Spectrum3_001006; Almotriptan (USAN); Spectrum2_000498; KBio3_001951; Spectrum_001884; D02824; KBio2_004976.
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Name: almotriptan
Name (isomeric): DB00918
Drug Type: small molecule
Brand: Almogran, Axert
Category: Serotonin Agonists, Selective Serotonin Agonists, Vasoconstrictor Agents, Anti-migraine Agents, Anti-inflammatory Agents
CAS number: 181183-52-8
Indication: For the treatment of acute migraine headache in adults
Almotriptan is a selective 5-hydroxytryptamine receptor subtype agonist indicated for the acute treatment of migraine attacks with or without aura in adults. Almotriptan is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine. Almotriptan is an agonist for a vascular 5-hydroxytryptamin...
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Mechanism of Action: Almotriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial blood vessel constriction.
Protein binding: 35%
Route of elimination: Almotriptan is eliminated primarily by renal excretion (about 75% of the oral dose), with approximately 40% of an administered dose excreted unchanged in urine. Approximately 13% of the administered dose is excreted via feces, both unchanged and metabolized.
Half Life: 3-4 hours
Clearance: 57 L/h [healthy] 34.2 L/h [moderate renal impairment (creatinine clearance between 31 and 71 mL/min)] 9.8 L/h [severe renal impairment (creatinine clearance between 10 and 30 mL/min)]
Affected organisms: Humans and other mammals
Food interaction:
The absorption is unaffected by food.
Take without regard to meals.
Drug interaction:
ErgotaminePossible severe and prolonged vasoconstriction
FluvoxamineIncreased risk of CNS adverse effects
TramadolIncreased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
SibutramineIncreased risk of CNS adverse effects
TrimipramineIncreased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
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