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QuickView for Dapsone (compound)
PubChem
| Name: | Dapsone |
|---|---|
| PubChem Compound ID: | 11128937 |
| Description: | A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8) |
| Molecular formula: | C12H12N2O2S |
| Molecular weight: | 256.351 g/mol |
DrugBank
Identification
| Name: | Dapsone |
|---|---|
| Name (isomeric): | DB00250 |
| Drug Type: | small molecule |
| Description: | A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8) |
| Synonyms: |
P,P-Sulfonylbisbenzenamine; P,P'-Diaminodiphenyl Sulfone; N, N'-Diphenyl Sulfondiamide; Dds, Diaphenylsulfone; Diaphenylsulphon; Diphenasone; DDS; Sulfonyldianiline; Sulphonyldianiline; Diaphenylsulfon.
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| Brand: | Eporal, Croysulphone, Diphone, Novophone, Sulfona, Sumicure S, Croysulfone, Recolip, Sulfanona-Mae, Normet, Sulfadione, Sulfona-Mae, Araldite Ht, Avlosulfon, Sulfon-Mere, ICI, Dubronax, Tarimyl, Udolac, Dimitone, Avlosulphone, Dumitone, Sulfone Ucb, Sulphon-Mere, Avlosulfone |
| Category: | Antimalarials, Anti-Infective Agents, Antimycobacterials, Folic Acid Antagonists, Anti-inflammatory Agents, Leprostatic Agents, Anti-Infectives |
| CAS number: | 80-08-0 |
Pharmacology
| Indication: | For the treatment and management of leprosy and dermatitis herpetiformis. |
|---|---|
| Pharmacology: |
Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties. Dapsone is the principal drug in a multidrug regimen recommended by the World Health Organization for the treatment of leprosy. As an anti-infective agent, it is also used for treating malaria and, recently, for Pneumocystic ...
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| Mechanism of Action: | Dapsone acts against bacteria and protozoa in the same way as sulphonamides, that is by inhibiting the synthesis of dihydrofolic acid through competition with para-amino-benzoate for the active site of dihydropteroate synthetase. The anti-inflammatory action of the drug is unrelated to its antibacterial action and is still not fully understood. |
| Absorption: | Bioavailability is 70 to 80% following oral administration. |
| Protein binding: | 70 to 90% |
| Biotransformation: | Hepatic, mostly CYP2E1-mediated. |
| Route of elimination: | Renal |
| Half Life: | 28 hours (range 10-50 hours) |
| Toxicity: | Overdosage might be expected to produce nasal congestion, syncope, or hallucinations. Measures to support blood pressure should be taken if necessary. |
| Affected organisms: | Mycobacteria |
Interactions
| Food interaction: |
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Targets
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