Bookmark
Forward
QuickView for Felbamate (compound)
PubChem
| Name: | felbamate |
|---|---|
| PubChem Compound ID: | 10562608 |
| Molecular formula: | C11H14N2O4 |
| Molecular weight: | 250.195 g/mol |
DrugBank
Identification
| Name: | felbamate |
|---|---|
| Name (isomeric): | DB00949 |
| Drug Type: | small molecule |
| Brand: | Felbamyl, Felbatol, Taloxa |
| Category: | Antiepileptic Agents, Neuroprotective Agents, Anticonvulsants |
| CAS number: | 25451-15-4 |
Pharmacology
| Indication: | For use only in those patients who respond inadequately to alternative treatments and whose epilepsy is so severe that a substantial risk of aplastic anemia and/or liver failure is deemed acceptable in light of the benefits conferred by its use. |
|---|---|
| Pharmacology: |
Felbamate is an antiepileptic indicated as monotherapy or as an adjunct to other anticonvulsants for the treatment of partial seizures resulting from epilepsy. Receptor-binding studies in vitro indicate that felbamate has weak inhibitory effects on GABA-receptor binding, benzodiazepine receptor binding, and is devoid of activity at the MK-80...
show more » |
| Mechanism of Action: |
The mechanism by which felbamate exerts its anticonvulsant activity is unknown, but in animal test systems designed to detect anticonvulsant activity, felbamate has properties in common with other marketed anticonvulsants. In vitro receptor binding studies suggest that felbamate may be an antagonist at the strychnine-insensitive glycine-reco...
show more » |
| Absorption: | >90% |
| Protein binding: | 20-36% |
| Biotransformation: | Hepatic |
| Half Life: | 20-23 hours |
| Clearance: | 26 +/- 3 mL/hr/kg [single 1200 mg dose] 30 +/- 8 mL/hr/kg [multiple daily doses of 3600 mg] |
| Toxicity: | LD50=5000 mg/kg (Orally in rats) |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
| ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug interaction: |
|
Targets
Enzymes
