QuickView for Liotrix (compound)

Summary
General Info

PubChem

PubChem Compound 165686

Name:	thyroxine, triiodothyronine drug combination
PubChem Compound ID:	165686
Molecular formula:	C₃₀H₂₃I₇N₂O₈
Molecular weight:	1427.84 g/mol
Synonyms:	39388-33-5; Thyrotan; 62651-59-6; 8061-58-3; 8065-29-0; Euthyral; L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, mixt. with O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; Thyreotom; Thyroxine - triiodothyronine mixt.; Triiodothyronine - thyroxine mixt.. show more » 39388-33-5; Thyrotan; 62651-59-6; 8061-58-3; 8065-29-0; Euthyral; L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, mixt. with O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; Thyreotom; Thyroxine - triiodothyronine mixt.; Triiodothyronine - thyroxine mixt.; L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, mixt. with O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine mixt. with O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine show less «

DrugBank

Identification

Name:	thyroxine, triiodothyronine drug combination
Name (isomeric):	DB01583
Drug Type:	small molecule
Brand:	Tyroplus, Levotrin, Thyrolar, Euthroid, Tiroide Amsa, Bitiron, Cynoplus, Euthyral, Combithyrex, Thyreotom, Novothyral, Levotiroxina, Dithyron, Eutroid, Novotiral, Prothyrid
Category:	Hormone Replacement Agents
CAS number:	8065-29-0

Pharmacology

Indication:	May be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic lymphocytic thyroiditis multinodular goiter, and in the management of thyroid cancer. May be used in conjunction with other antithyroid agents to treat thyrotoxicosis to prevent goitrogenesis and hypothyroidism. May also be used for differential diagnosis of suspected mild hyperthyroidism or thyroid gland autonomy.
Pharmacology:	Thyroid hormone drugs are natural or synthetic preparations containing T₄ or T₃ or both. T₄ and T₃ are produced in the human thyroid gland by the iodination and coupling of the amino acid tyrosine. Liotrix is a synthetic preparation of T4 and T3 in a 4:1 weight-based ratio. These hormones enhance oxygen c... show more » Thyroid hormone drugs are natural or synthetic preparations containing T₄ or T₃ or both. T₄ and T₃ are produced in the human thyroid gland by the iodination and coupling of the amino acid tyrosine. Liotrix is a synthetic preparation of T4 and T3 in a 4:1 weight-based ratio. These hormones enhance oxygen consumption by most tissues of the body and increase the basal metabolic rate and the metabolism of carbohydrates, lipids and proteins. Thus, they exert a profound influence on every organ system in the body and are of particular importance in the development of the central nervous system. show less «
Mechanism of Action:	The hormones, T₄ and T₃, are tyrosine-based hormones produced by the thyroid gland. Iodine is an important component in their synthesis. The major secreted form of thyroid hormone is T4. T4 is converted T3, the more active thyroid hormone, by deiodinases in peripheral tissues. T3 acts in the body to increase basal metabolic ra... show more » The hormones, T₄ and T₃, are tyrosine-based hormones produced by the thyroid gland. Iodine is an important component in their synthesis. The major secreted form of thyroid hormone is T4. T4 is converted T3, the more active thyroid hormone, by deiodinases in peripheral tissues. T3 acts in the body to increase basal metabolic rate, alter protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline). Thyroid hormones are essential for proper development and differentiation of all cells of the human body. T₄ and T₃ regulate protein, fat and carbohydrate metabolism to varying extents. The most pronounced effect of the hormones is in altering how human cells use energetic compounds. The thyroid hormone derivatives bind to the thyroid hormone receptors initially to initiate their downstream effects. show less «
Route of elimination:	Thyroid hormones are primarily eliminated by the kidneys.
Toxicity:	Hypermetabolic state indistinguishable from thyrotoxicosis of endogenous origin. Symptoms of thyrotoxicosis include weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, tachycardia, increased pulse and blood pressure, cardiac arrhythmias, tremors, insomnia, heat intolerance, fever, and menstrual irregularities.
Affected organisms:	Humans and other mammals

Interactions

Food interaction:

Absorption increased in fasting state and decreased in malabsorption states.

Oral administration with infant soybean formula, soybean flour, cotton seed meal, walnuts, foods containing large amounts of fiber, ferrous sulfate, and antacids may decrease drug absorption.

Iron and calcium may interfere with absorption. Space doses at least one hour before or after iron or calcium intake.

Take 30-60 minutes before breakfast.

Consistent administration in relation to meals is recommended.

Drug interaction:

Calcium Acetate	Calcium salts such as calcium acetate may diminish the therapeutic effect of thyroid products such as liotrix. Separate the doses of the thyroid product and the oral calcium supplement by at least 4 hours. Monitor for decreased therapeutic effects of thyroid products if an oral calcium supplement is initiated/dose increased, or increased effects if an oral calcium supplement is discontinued/dose decreased.
Colestipol	The resin, colestipol, decreases the absorption of the thyroid hormone, liotrix.
Cholestyramine	The resin, cholestyramine, decreases the absorption of the thyroid hormone, liotrix.
Digoxin	The thyroid hormone, liotrix, decreases the effect of digoxin.
Warfarin	Liotrix may contribute to the anticoagulant effect of warfarin by increasing the metabolism of vitamin K-dependent clotting factors. Monitor for changes in prothrombin time and anticoagulant effects if liotrix is initiated, discontinued or dose changed.