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QuickView for Thiethlperazine Novartis Brand (compound)
PubChem
| Name: | Thiethylperazine |
|---|---|
| PubChem Compound ID: | 11954258 |
| Description: | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) |
| Molecular formula: | C30H41N3O10S2 |
| Molecular weight: | 667.793 g/mol |
| Synonyms: |
52239-63-1; Torecan (TN); Thiethylperazine malate (JAN); Thiethylperazine malate; Torecan; D02610
|
DrugBank
Identification
| Name: | Thiethylperazine |
|---|---|
| Name (isomeric): | DB00372 |
| Drug Type: | small molecule |
| Description: | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) |
| Synonyms: |
Ethylthioperazine; Theithylperazine
|
| Brand: | Torecan, Norzine |
| Category: | Antiemetics, Dopamine Antagonists, Anti-emetics |
| CAS number: | 1420-55-9 |
Pharmacology
| Indication: | For the treatment or relief of nausea and vomiting. |
|---|---|
| Pharmacology: |
Thiethylperazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacological...
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| Mechanism of Action: |
Thiethylperazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Thiethylperazine's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than a...
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| Protein binding: | 60% |
| Route of elimination: | Thiethylperazine is eliminated in the urine. |
| Toxicity: | Manifestations of acute overdosage of TORECAN (thiethylperazine) can be expected to reflect the CNS effects of the drug and include extrapyramidal symptoms (E.P.S), confusion and convulsions with reduced or absent reflexes, respiratory depression and hypotension. |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
