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QuickView for apomorphine (compound)
PubChem
| Name: | Apomorphine |
|---|---|
| PubChem Compound ID: | 107882 |
| Description: | A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use. |
| Molecular formula: | C34H38Cl2N2O5 |
| Molecular weight: | 625.581 g/mol |
| Synonyms: |
(6aR)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo(de,g)chinolin-10,11-diol hydrochlorid; 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hemihydrate, (R)-; Uprima (TN); Apmorphine hydrochloride hemihydrate; D02004; Uprima; 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hydrate (2:1), (6aR)-; 6abeta-Aporphine-10,11-diol hydrochloride hemihydrate; Apomorphine hydrochloride; Apomorphin hydrochlorid wasser (2/1).
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DrugBank
Identification
| Name: | Apomorphine |
|---|---|
| Name (isomeric): | DB00714 |
| Drug Type: | small molecule |
| Description: | A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use. |
| Synonyms: |
Apomorphinium Chloride Hemihydrate; L-Apomorphine; Apomorfin; VR-040; Apomorphine Hydrochloride; Apormorphine; VR004; VR-400; Apomorphine Hydrochloride Hemihydrate
|
| Brand: | Uprima, Ixense, Apokyn |
| Brand name mixture: | Homeopathic Remedy Thc No. 48 Dps(Antimony Trisulfide + Apomorphine + Ipecac + Phosphorus + Pulsatilla) |
| Category: | Antidyskinetics, Antiparkinson Agents, Dopamine Agonists |
| CAS number: | 41372-20-7 |
Pharmacology
| Indication: | For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease. |
|---|---|
| Pharmacology: | Apomorphine is a type of dopaminergic agonist, a morphine derivative which primarily affects the hypothalamic region of the brain. Drugs containing this substance are sometimes used in the treatment of Parkinson's disease or erectile dysfunction. In higher doses it is a highly effective emetic. |
| Mechanism of Action: |
The precise mechanism of action of apomorphine as a treatment for Parkinson's disease is unknown, although it is believed to be due to stimulation of post-synaptic dopamine D2-type receptors within the brain. Apomorphine has been shown to improve motor function in an animal model of Parkinson's disease. In particular, apomorphine attenuates the mot...
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| Absorption: | 100% following subcutaneous administration |
| Protein binding: | ~50%-albumin |
| Biotransformation: | Hepatic |
| Half Life: | 40 minutes (range 30 - 60 minutes) |
| Clearance: | 223 L/hr |
| Toxicity: | LD50=0.6 mmoles/kg (mice, intraperitoneal) |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
