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QuickView for Thiothixene (compound)


PubChem
Name: Thiothixene
PubChem Compound ID: 5454
Description: A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Molecular formula: C23H29N3O2S2
Molecular weight: 443.627 g/mol
Synonyms:
Orbinamon; Thiothixene; CP 12252-1; N, N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2 -sulfonamide; Tiotixene; P-4657 B; KBio2_001548; Navan; KBio1_000335; Navaron.
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DrugBank
Identification
Name: Thiothixene
Name (isomeric): DB01623
Drug Type: small molecule
Description: A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Synonyms:
Tiotixene; Tiotixenum [inn-latin]; (e)-thiothixene; Thiothixine; Tiotixeno [inn-spanish]; Cis-thiothixene
Brand: Orbinamon, Navan, Navaron, Navane
Category: Thioxanthenes, Dopamine Antagonists, Antipsychotic Agents
CAS number: 5591-45-7
Pharmacology
Indication: For the management of schizophrenia.
Pharmacology:
Thiothixene is an antipsychotic of the thioxanthene series. Navane possesses certain chemical and pharmacological similarities to the piperazine phenothiazines and differences from the aliphatic group of phenothiazines. Although widely used in the treatment of schizophrenia for several decades, thiothixene is seldom used today in favor of atypical ...
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Mechanism of Action:
Thiothixene acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuat...
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Biotransformation: Hepatic.
Half Life: 10-20 hours
Toxicity: Symptoms of overdose include central nervous system depression, coma, difficulty swallowing, dizziness, drowsiness, head tilted to the side, low blood pressure, muscle twitching, rigid muscles, salivation, tremors, walking disturbances, and weakness.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid alcohol
Drug interaction:
CisaprideMay cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
FlupenthixolMay cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
HalofantrineMay cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
LevodopaThiothixene may antaonize the effects of the anti-Parkinsonian agent, Levodopa. Consider alternate therapy or monitor for decreased effects of both agents.
PentamidineMay cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
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