Name: | pramipexol |
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PubChem Compound ID: | 119569 |
Molecular formula: | C10H19Cl2N3S |
Molecular weight: | 284.249 g/mol |
Synonyms: |
SND-919CL2Y; 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, (S)-; PNU-98528E; Sifrol; BI-Sifrol; Mirapexin; SND-919; U-98528E; 104632-25-9; SND 19.
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Name: | pramipexol |
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Name (isomeric): | DB00413 |
Drug Type: | small molecule |
Synonyms: |
Pramipexole hydrochloride; Pramipexol [Spanish]; Pramipexole 2HCl Monohydrate; Pramipexol; Pramipexolum [Latin]; Furfuryl Acetate
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Brand: | Mirapex |
Category: | Antidyskinetics, Antioxidants, Free Radical Scavengers, Antiparkinson Agents, Dopamine Agonists |
CAS number: | 104632-26-0 |
Indication: | For the treatment of signs and symptoms of idiopathic Parkinson's disease |
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Pharmacology: |
Pramipexole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes. The relevance of D3 receptor binding in Parkinson's disease is unknown. The precise mechanism of action of Pramipexole...
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Mechanism of Action: | The precise mechanism of action of Pramipexole as a treatment for Parkinson's disease is unknown, although it is believed to be related to its ability to stimulate dopamine receptors in the striatum. |
Absorption: | Rapid. Absolute bioavailability is greater than 90%, indicating that pramipexole is well absorbed and undergoes little presystemic metabolism. Food does not affect the extent of absorption. |
Protein binding: | About 15% bound to plasma proteins. |
Biotransformation: | No metabolites have been identified in plasma or urine. |
Route of elimination: | Urinary excretion is the major route of pramipexole elimination, with 90% of a pramipexole dose recovered in urine, almost all as unchanged drug. Nonrenal routes may contribute to a small extent to pramipexole elimination, although no metabolites have been identified in plasma or urine. |
Half Life: | 8 hours |
Clearance: | renal cl=400 mL/min |
Affected organisms: | Humans and other mammals |
Food interaction: |
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