Bookmark
Forward
QuickView for Amphetamine (compound)
PubChem
| Name: | Amphetamine |
|---|---|
| PubChem Compound ID: | 10220277 |
| Description: | A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE. |
| Molecular formula: | C9H15NO4S |
| Molecular weight: | 233.286 g/mol |
DrugBank
Identification
| Name: | Amphetamine |
|---|---|
| Name (isomeric): | DB00182 |
| Drug Type: | small molecule |
| Description: | A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE. |
| Synonyms: |
Phenylisopropylamine; dl-1-Phenyl-2-aminopropane; (+/-)-Benzedrine; 3-Methoxyphenylisopropylamine; 3-Methoxy-a-methylbenzeneethanamine; dl-Amphetamine; Fenylo-izopropylaminyl; [1-(3-Methoxyphenyl)-2-propyl]amine; Methamphetamine HCL; Amphetamine Sulfate.
show more » |
| Brand: | Paredrine, Dexampex, Anorexine, Benzedrine, Ferndex, Desoxyn, Actedron, Phenamine, Percomon, Norephedrane, Profamina, Finam, Methampex, Raphetamine, Rhinalator, Isoamyne, Psychedrine, Dextrostat, Phenedrine, Sympamine, Mecodrin, Novydrine, Elastonon, Adipan, Simpatina, Simpatedrin, Oktedrin, Ortedrine, Anorexide, Dexedrine, Weckamine, Fenamin, Allodene, Propisamine, Isomyn, Benzolone, Isoamycin, Sympatedrine, Sympamin, Benzebar |
| Brand name mixture: | Adderall XR 25mg(Amphetamine Aspartate + Amphetamine Sulfate + Dextroamphetamine Saccharate + Dextroamphetamine Sulfate), Adderall XR 20mg(Amphetamine Aspartate + Amphetamine Sulfate + Dextroamphetamine Saccharate + Dextroamphetamine Sulfate), Adderall XR 30mg(Amphetamine Aspartate + Amphetamine Sulfate + Dextroamphetamine Saccharate + Dextroamp... show more » |
| Category: | Amphetamines, Dopamine Uptake Inhibitors, Adrenergic Agents, Sympathomimetics, Adrenergic Uptake Inhibitors, Central Nervous System Stimulants, Dopamine Agents |
| CAS number: | 300-62-9 |
Pharmacology
| Indication: | For treatment of Attention Deficit Disorder with Hyperactivity (ADDH) and narcolepsy in children. |
|---|---|
| Pharmacology: | Amphetamine and dextroamphetamine, non-catechloamine sypathomimetic agents, are used in combination to treat attention-deficit hyperactivity disorder (ADHD) or narcolepsy. Adderall consists of equivalent amounts of amphetamine aspartate, amphetamine sulfate, dextroamphetamine saccharate, and dextroamphetamine sulfate. |
| Mechanism of Action: |
Amphetamines stimulate the release of norepinephrine from central adrenergic receptors. At higher dosages, they cause release of dopamine from the mesocorticolimbic system and the nigrostriatal dopamine systems. Amphetamine may also act as a direct agonist on central 5-HT receptors and may inhibit monoamine oxidase (MAO). In the periphery, amphetam...
show more » |
| Absorption: | Amphetamine forms easily absorbed molecules that are highly lipid soluble |
| Protein binding: | 15-40% |
| Biotransformation: | Hepatic |
| Half Life: | 10 hours |
| Toxicity: | LD50=180 mg/kg(subcutaneous injection in rat). The most common presenting symptoms seen are agitation, hallucinations, suicidal behaviour, and chest pain. |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
|
|---|
Targets
Enzymes
Transporters
