Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for Trifluoperazine (compound)

Name: Trifluoperazine
PubChem Compound ID: 2913535
Description: A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.
Molecular formula: C21H25ClF3N3S
Molecular weight: 443.957 g/mol
SMR000059133; Trifluoperazine dihydrochloride; MLS000069471
Name: Trifluoperazine
Name (isomeric): DB00831
Drug Type: small molecule
Description: A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.
Trifluoroperazine Dihydrochloride; Trifluperazine; Trifluoperazine Dihydrochloride; Trifluoperazina; Trifluoroperazine Hydrochloride; Trifluoperazine Hydrochloride; Trifluoperazine HCl; Trifluroperizine; Tryptazine Dihydrochloride; Trifluoroperazine.
show more »
Brand: Triphthazine, Modalina, Stellazine, Stelazine, Tryptazine, Triphtazin, Fluoperazine, Eskazinyl, Jatroneural, Eskazine, Trazine, Triphthasine, Novo-Trifluzine, Terfluzine, Triperazine, Triftazin, Triftazine, Triphtazine, Synklor, Triflurin
Brand name mixture: Stelabid No 2(Isopropamide Iodide + Trifluoperazine Hydrochloride), Stelabid No 1(Isopropamide Iodide + Trifluoperazine Hydrochloride), Stelabid Forte(Isopropamide Iodide + Trifluoperazine Hydrochloride), Parmodalin(Tranylcypromine + Trifluoperazine)
Category: Phenothiazines, Antiemetics, Dopamine Antagonists, Antipsychotic Agents, Antipsychotics
CAS number: 117-89-5
Indication: For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation.
Pharmacology: Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Trifluoperazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.
Mechanism of Action: Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Biotransformation: Hepatic.
Half Life: 10-20 hours
Toxicity: Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.
Affected organisms: Humans and other mammals
Drug interaction:
GrepafloxacinIncreased risk of cardiotoxicity and arrhythmias
LevofloxacinIncreased risk of cardiotoxicity and arrhythmias
AmphetamineDecreased anorexic effect, may increase psychotic symptoms
MetrizamideIncreased risk of convulsions
SparfloxacinIncreased risk of cardiotoxicity and arrhythmias
show more »