Name: | Trifluoperazine |
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PubChem Compound ID: | 2913535 |
Description: | A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic. |
Molecular formula: | C21H25ClF3N3S |
Molecular weight: | 443.957 g/mol |
Synonyms: |
SMR000059133; Trifluoperazine dihydrochloride; MLS000069471
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Name: | Trifluoperazine |
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Name (isomeric): | DB00831 |
Drug Type: | small molecule |
Description: | A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic. |
Synonyms: |
Trifluoroperazine Dihydrochloride; Trifluperazine; Trifluoperazine Dihydrochloride; Trifluoperazina; Trifluoroperazine Hydrochloride; Trifluoperazine Hydrochloride; Trifluoperazine HCl; Trifluroperizine; Tryptazine Dihydrochloride; Trifluoroperazine.
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Brand: | Triphthazine, Modalina, Stellazine, Stelazine, Tryptazine, Triphtazin, Fluoperazine, Eskazinyl, Jatroneural, Eskazine, Trazine, Triphthasine, Novo-Trifluzine, Terfluzine, Triperazine, Triftazin, Triftazine, Triphtazine, Synklor, Triflurin |
Brand name mixture: | Stelabid No 2(Isopropamide Iodide + Trifluoperazine Hydrochloride), Stelabid No 1(Isopropamide Iodide + Trifluoperazine Hydrochloride), Stelabid Forte(Isopropamide Iodide + Trifluoperazine Hydrochloride), Parmodalin(Tranylcypromine + Trifluoperazine) |
Category: | Phenothiazines, Antiemetics, Dopamine Antagonists, Antipsychotic Agents, Antipsychotics |
CAS number: | 117-89-5 |
Indication: | For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation. |
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Pharmacology: | Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Trifluoperazine has not been shown effective in the management of behaviorial complications in patients with mental retardation. |
Mechanism of Action: | Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. |
Biotransformation: | Hepatic. |
Half Life: | 10-20 hours |
Toxicity: | Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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