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QuickView for Mesoridazine (compound)

Name: Mesoridazine
PubChem Compound ID: 3246545
Description: A phenothiazine antipsychotic with effects similar to CHLORPROMAZINE.
Molecular formula: C21H26N2OS2
Molecular weight: 386.576 g/mol
NCGC00014529; NSC-186066; NCIStruc1_001962; NCIStruc2_001598
Name: Mesoridazine
Name (isomeric): DB00933
Drug Type: small molecule
Description: A phenothiazine antipsychotic with effects similar to CHLORPROMAZINE.
Thioridazine Monosulfoxide Analog; Thioridazine Thiomethyl Sulfoxide; TPS-23; Thioridazien Thiomethyl Sulfoxide; TPS23
Brand: Calodal, Lidanar, Serentil Concentrate, Serentil, Lidanil
Category: Phenothiazines, Dopamine Antagonists, Antipsychotic Agents, Antipsychotics
CAS number: 5588-33-0
Indication: Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses.
Mesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer. Pharmacological studies in laboratory animals have established that mesoridazine has a spectrum of pharmacodynamic actions typical of a major tranquilizer. In common with other tranquilizers it inhibits spontaneous motor activity in mice, prolongs thio...
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Mechanism of Action:
Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. In addition, the phenothiazines exhibit at least part of their activities through depression of hypothal...
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Absorption: Well absorbed from the gastrointestinal tract.
Protein binding: 4%
Half Life: 24 to 48 hours
Toxicity: Oral LD50 is 560 ± 62.5 mg/kg and 644 ± 48 mg/kg in mouse and rat, respectively. Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system.
Affected organisms: Humans and other mammals
Food interaction:
Take with food to reduce irritation.
Drug interaction:
ErythromycinIncreased risk of cardiotoxicity and arrhythmias
GrepafloxacinIncreased risk of cardiotoxicity and arrhythmias
PentamidineIncreased risk of cardiotoxicity and arrhythmias
LevofloxacinIncreased risk of cardiotoxicity and arrhythmias
AmphetamineDecreased anorexic effect, may increase psychotic symptoms
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