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QuickView for Flurazepam (compound)
PubChem
| Name: | Flurazepam |
|---|---|
| PubChem Compound ID: | 14434 |
| Description: | A benzodiazepine derivative used mainly as a hypnotic. |
| Molecular formula: | C21H25Cl3FN3O |
| Molecular weight: | 460.799 g/mol |
| Synonyms: |
Flurazepam hydrochloride (USP); Lunipax; Flurazepam Hydrochloride; EINECS 214-630-0; Felison; Dalmane (TN); D00695; FLURAZEPAM HYDROCHLRIDE; Benozil; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, dihydrochloride.
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DrugBank
Identification
| Name: | Flurazepam |
|---|---|
| Name (isomeric): | DB00690 |
| Drug Type: | small molecule |
| Description: | A benzodiazepine derivative used mainly as a hypnotic. |
| Synonyms: |
Flurazepam HCL
|
| Brand: | Insumin, Felmane, Stauroderm, Paxane, Noctosom, Dalmadorm, Valdorm, Dalmane, Somnol, Flunox, Felison |
| Category: | Anti-anxiety Agents, GABA Modulators, Hypnotics and Sedatives |
| CAS number: | 17617-23-1 |
Pharmacology
| Indication: | For short-term and intermittent use in patients with recurring insomnia and poor sleeping habits |
|---|---|
| Pharmacology: | Flurazepam, a benzodiazepine derivative, is a hypnotic agent which does not appear to decrease dream time as measured by rapid eye movements (REM). Furthermore, it decreases sleep latency and number of awakenings for a consequent increase in total sleep time. |
| Mechanism of Action: | Flurazepam binds to an allosteric site on GABA-A receptors. Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. |
| Absorption: | Flurazepam hydrochloride is rapidly (30 minutes) absorbed from the gastrointestinal tract |
| Protein binding: | 83% |
| Biotransformation: | Flurazepam is rapidly metabolized and is excreted primarily in the urine. Both hydroxyethyl flurazepam (the major metabolite) and N-desalkyl flurazepam are active. The N-desalkyl metabolite is slowly excreted in the urine as the conjugated form |
| Route of elimination: | Flurazepam is rapidly metabolized and is excreted primarily in the urine. Less than 1% of the dose is excreted in the urine as N1-desalkyl-flurazepam. |
| Half Life: | The mean apparent half-life of flurazepam is 2.3 hours. The half life of elimination of N1-des-alkyl- flurazepam ranged from 47 to 100 hours |
| Toxicity: | Coma, confusion, low blood pressure, sleepiness |
| Affected organisms: | Humans and other mammals |
Interactions
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Targets
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