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QuickView for Danazol (compound)


PubChem
Name: Danazol
PubChem Compound ID: 11416460
Description: A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Molecular formula: C22H27NO2
Molecular weight: 337.455 g/mol
Synonyms:
ZINC04029104
DrugBank
Identification
Name: Danazol
Name (isomeric): DB01406
Drug Type: small molecule
Description: A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Brand: Danocrine, Chronogyn, Anatrol, Cyclomen
Category: Estrogen Antagonists
CAS number: 17230-88-5
Pharmacology
Indication: For the treatment of endometriosis and fibrocystic breast disease (in patients unresponsive to simple measures). Also used for the prophylactic treatment of all types of hereditary angioedema in males and females.
Pharmacology:
Danazol is a derivative of the synthetic steroid ethisterone, a modified testosterone. It was approved by the U.S. Food and Drug Administration (FDA) as the first drug to specifically treat endometriosis, but its role as a treatment for endometriosis has been largely replaced by the gonadotropin-releasing hormone (GnRH) agonists. Danazol has antigo...
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Mechanism of Action:
As a gonadotropin inhibitor, danazol suppresses the pituitary-ovarian axis possibly by inhibiting the output of pituitary gonadotropins. Danazol also depresses the preovulatory surge in output of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), thereby reducing ovarian estrogen production. Danazol may also directly inhibits ovarian ...
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Biotransformation: Hepatic, to principal metabolites, ethisterone and 17-hydroxymethylethisterone.
Half Life: Approximately 24 hours.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take without regard to meals.
Drug interaction:
CarbamazepineDanazol may decrease the metabolism of carbamazepine. Monitor for changes in the therapeutic and adverse effects of carbamazepine if danazol is initiated, discontinued or dose changed.
LovastatinRisk of severe myopathy/rhabdomyolysis with this combination
AnisindioneThe androgen, danazol, may increase the anticoagulant effect of anisindione.
AcenocoumarolThe androgen, danazol, may increase the anticoagulant effect of acenocoumarol.
TacrolimusDanazol may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Danazol therapy is initiated, discontinued or altered.
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