Name: | Danazol |
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PubChem Compound ID: | 11416460 |
Description: | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. |
Molecular formula: | C22H27NO2 |
Molecular weight: | 337.455 g/mol |
Synonyms: |
ZINC04029104
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Name: | Danazol |
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Name (isomeric): | DB01406 |
Drug Type: | small molecule |
Description: | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. |
Brand: | Danocrine, Chronogyn, Anatrol, Cyclomen |
Category: | Estrogen Antagonists |
CAS number: | 17230-88-5 |
Indication: | For the treatment of endometriosis and fibrocystic breast disease (in patients unresponsive to simple measures). Also used for the prophylactic treatment of all types of hereditary angioedema in males and females. |
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Pharmacology: |
Danazol is a derivative of the synthetic steroid ethisterone, a modified testosterone. It was approved by the U.S. Food and Drug Administration (FDA) as the first drug to specifically treat endometriosis, but its role as a treatment for endometriosis has been largely replaced by the gonadotropin-releasing hormone (GnRH) agonists. Danazol has antigo...
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Mechanism of Action: |
As a gonadotropin inhibitor, danazol suppresses the pituitary-ovarian axis possibly by inhibiting the output of pituitary gonadotropins. Danazol also depresses the preovulatory surge in output of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), thereby reducing ovarian estrogen production. Danazol may also directly inhibits ovarian ...
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Biotransformation: | Hepatic, to principal metabolites, ethisterone and 17-hydroxymethylethisterone. |
Half Life: | Approximately 24 hours. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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Drug interaction: |
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