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PubChem
| Name: | Piperacillin |
|---|---|
| PubChem Compound ID: | 153902 |
| Description: | Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics. |
| Molecular formula: | C23H27N5O7S |
| Molecular weight: | 517.556 g/mol |
DrugBank
Identification
| Name: | Piperacillin |
|---|---|
| Name (isomeric): | DB00319 |
| Drug Type: | small molecule |
| Description: | Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics. |
| Synonyms: |
Piperacillin Anhydrous
|
| Brand: | Pipracil |
| Brand name mixture: | Tazocin(Piperacillin (Piperacillin Sodium) + Tazobactam (Tazobactam Sodium)) |
| Category: | Anti-Bacterial Agents, Penicillins |
| CAS number: | 66258-76-2 |
Pharmacology
| Indication: | For the treatment of polymicrobial infections. |
|---|---|
| Pharmacology: |
Piperacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Piperacillin has in vitro activity against ...
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| Mechanism of Action: | By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin interferes with an autolysin inhibitor. |
| Absorption: | Not absorbed following oral administration. |
| Biotransformation: | Largely not metabolized. |
| Route of elimination: | As with other penicillins, PIPRACIL is eliminated primarily by glomerular filtration and tubular secretion; it is excreted rapidly as unchanged drug in high concentrations in the urine. Because PIPRACIL is excreted by the biliary route as well as by the renal route, it can be used safely in appropriate dosage in patients with severely restricted kidney function. |
| Half Life: | 36-72 minutes |
| Clearance: | 32 - 41 mL/min/1.73 m2 124 - 160 mL/min/1.73 m2 [older pediatric patients] |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Drug interaction: |
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Targets
Transporters
