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QuickView for Triflupromazine (compound)

Name: Triflupromazine
PubChem Compound ID: 10618054
Description: A phenothiazine used as an antipsychotic agent and as an antiemetic.
Molecular formula: C18H19F3N2S
Molecular weight: 353.411 g/mol
Name: Triflupromazine
Name (isomeric): DB00508
Drug Type: small molecule
Description: A phenothiazine used as an antipsychotic agent and as an antiemetic.
Brand: Siquil, Fluopromazine, Adazine, Trifluopromazine, Psyquil
Category: Antiemetics, Dopamine Antagonists, Antipsychotic Agents, Antipsychotics
CAS number: 146-54-3
Indication: Used mainly in the management of psychoses. Also used to control nausea and vomiting.
Triflupromazine is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists. Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. It reduces anxiety, emotional withdrawal, hallucinations, disorganized thoughts, blunted mood, and suspic...
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Mechanism of Action:
Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve i...
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Absorption: Absorption may be erratic and peak plasma concentrations show large interindividual differences.
Protein binding: Very high (90% or more).
Biotransformation: Hepatic.
Toxicity: Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.
Affected organisms: Humans and other mammals
Drug interaction:
GrepafloxacinIncreased risk of cardiotoxicity and arrhythmias
LevofloxacinIncreased risk of cardiotoxicity and arrhythmias
TerfenadineIncreased risk of cardiotoxicity and arrhythmias
GuanethidineTriflupromazine may decrease the effect of guanethidine.
GalantaminePossible antagonism of action
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