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QuickView for Triflupromazine (compound)
PubChem
| Name: | Triflupromazine |
|---|---|
| PubChem Compound ID: | 10618054 |
| Description: | A phenothiazine used as an antipsychotic agent and as an antiemetic. |
| Molecular formula: | C18H19F3N2S |
| Molecular weight: | 353.411 g/mol |
DrugBank
Identification
| Name: | Triflupromazine |
|---|---|
| Name (isomeric): | DB00508 |
| Drug Type: | small molecule |
| Description: | A phenothiazine used as an antipsychotic agent and as an antiemetic. |
| Brand: | Siquil, Fluopromazine, Adazine, Trifluopromazine, Psyquil |
| Category: | Antiemetics, Dopamine Antagonists, Antipsychotic Agents, Antipsychotics |
| CAS number: | 146-54-3 |
Pharmacology
| Indication: | Used mainly in the management of psychoses. Also used to control nausea and vomiting. |
|---|---|
| Pharmacology: |
Triflupromazine is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists. Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. It reduces anxiety, emotional withdrawal, hallucinations, disorganized thoughts, blunted mood, and suspic...
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| Mechanism of Action: |
Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve i...
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| Absorption: | Absorption may be erratic and peak plasma concentrations show large interindividual differences. |
| Protein binding: | Very high (90% or more). |
| Biotransformation: | Hepatic. |
| Toxicity: | Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness. |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
Transporters
