Name: | Vincristine |
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PubChem Compound ID: | 11957714 |
Description: | Antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.) |
Molecular formula: | C46H58N4O14S |
Molecular weight: | 923.037 g/mol |
Synonyms: |
EU-0101208
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Name: | Vincristine |
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Name (isomeric): | DB00541 |
Drug Type: | small molecule |
Description: | Antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.) |
Synonyms: |
Vincristina [DCIT]; Z-D-Val-Lys(Z)-OH; VCR; 22-Oxovincaleukoblastine; Vincristine Sulfate; Vincristinum [INN-Latin]; VIN; LCR; Leurocristine; Vincrystine.
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Brand: | Onco TCS, Marqibo, Oncovin, Vincristine Sulfate PFS, Vincasar PFS, Vincrex, Vincasar, Vinkristin |
Category: | Antineoplastic Agents, Tubulin Modulators, Antineoplastic Agents, Phytogenic |
CAS number: | 57-22-7 |
Indication: | For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis |
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Pharmacology: |
Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful sinc...
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Mechanism of Action: |
The antitumor activity of Vincristine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Vincristine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca2+-transport ATPase activity, 3) cellular respir...
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Protein binding: | ~75% |
Biotransformation: | Hepatic |
Half Life: | 19-155 hours |
Toxicity: | IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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