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QuickView for Phenylbutazone (compound)
PubChem
| Name: | Phenylbutazone |
|---|---|
| PubChem Compound ID: | 4781 |
| Description: | A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS. |
| Molecular formula: | C19H20N2O2 |
| Molecular weight: | 308.374 g/mol |
| Synonyms: |
Merizone; Butylpyrin; Butaphen; DA-192; Phebuzine; Phenyl-mobuzon; Elmedal; Tevcodyne; 4297-92-1; Ticinil.
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DrugBank
Identification
| Name: | Phenylbutazone |
|---|---|
| Name (isomeric): | DB00812 |
| Drug Type: | small molecule |
| Description: | A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS. |
| Brand: | Butoz, Fenylbutazon, Anerval, Ecobutazone, Lingel, Mepha-Butazon, Wescozone, Schemergin, Tevcodyne, Rubatone, Mephabutazone, Butartril, Busone, Scanbutazone, Merizone, Robizon-V, Butacompren, Robizone-V, Butylpyrin, Uzone, Fenartil, Intrazone, Praecirheumin, Usaf Ge-15, Bute, Butarecbon, Butapirazol, Reumasyl, Phenopyrine, Benzone, Fenilidina, Artizin, Butazolidin, Reumazol, Rectofasa, Ia-But, Mephabutazon, Azdid, Bizolin, Phenbutazone, Phenylbutazonum, Buta Phen, Artrizone, Butalgina, Butazolidine, Reumazin, Antadol, Tencodyne, Alka Butazolidin, Phenyzone, Azobutyl, Intrabutazone, Arthrizon, Bunetzone, Buvetzone, Diphebuzol, Butapyrazole, Alindor, Febuzina, Malgesic, Phenyl-Mobuzon, Butadion, Phenylbutaz, Eributazone, Kadol, Todalgil, Butazone, Butagesic, Novophenyl, Butazona, Butatron, Zolaphen, Butazina, Alqoverin, Apo-Phenylbutazone, Pyrazolidin, Butalidon, Anpuzone, Fenilbutine, Exrheudon N, Fenibutal, Butapirazole, Phenyzene, Artropan, Azolid, Butidiona, Reumuzol, Pyrabutol, Alkabutazona, Zolidinum, Fenilbutina, Pirarreumol B, Diphenylbutazone, Equi Bute, Nadozone, Phebuzine, Ipsoflame, Fenilbutazona, VAC-10, Fenotone, Pirarreumol "B", Diozol, Robizone, Fenibutasan, Butone, Elmedal, Digibutina, Fenibutol, Tazone, Reudox, Butadiona, Neo-Zoline, Shigrodin, Tetnor, Buzon, Butaluy, Ambene, Phenbutazol, Ticinil, Bizolin 200, Betazed, Butiwas-Simple, Phebuzin, Artrizin, Reupolar, 'Esteve', Intalbut, Equipalazone, Nadazone, Therazone, Reudo, Butacote, Diossidone, Reumune, Chembutazone, Fenibutazona, B.T.Z., Butadione, Butartrina, Anuspiramin, Cotylbutazone |
| Brand name mixture: | Alka Phenylbutazone Tab(Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone), Phenylone Plus Tab(Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone), Alka Phenyl Tab(Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone) |
| Category: | Anti-inflammatory Agents, Nonsteroidal Anti-inflammatory Agents (NSAIAs) |
| CAS number: | 50-33-9 |
Pharmacology
| Indication: | For the treatment of backache and ankylosing spondylitis |
|---|---|
| Pharmacology: |
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacy...
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| Mechanism of Action: | Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues. |
| Toxicity: | Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat) |
| Affected organisms: | Humans and other mammals |
Interactions
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