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QuickView for Sucralfate (compound)

Name: Sucralfate
PubChem Compound ID: 6398588
Description: A basic aluminum complex of sulfated sucrose.
Molecular formula: C11H18AlO38S8-8
Molecular weight: 1041.75 g/mol
Sucralfate; MLS000028585; SMR000058992
Name: Sucralfate
Name (isomeric): DB00364
Drug Type: small molecule
Description: A basic aluminum complex of sulfated sucrose.
Brand: Carafate, Ulcerlmin, Ulcogant, Ulcerban, Sulcrate Suspension Plus, Ulcermin, Apo-sucralfate, Antepsin, Sucramal, Ulcar, Sulcrate
Category: Anti-Ulcer Agents
CAS number: 54182-58-0
Indication: For the short-term treatment (up to 8 weeks) of active duodenal ulcer, as well as maintenance therapy for duodenal ulcer patients at reduced dosage (1 gram twice a day) after healing of acute ulcers. Also used for the short-term treatment of gastric ulcer.
Sucralfate is a prescription medication used to treat peptic ulcers. The current clinical uses of sucralfate are limited. It is effective for the healing of duodenal ulcers, but it is not frequently used for this since more effective drugs (e.g. proton pump inhibitors) have been developed. Although the mechanism of sucralfate's ability to accelerat...
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Mechanism of Action:
Although sucralfate's mechanism is not entirely understood, there are several factors that most likely contribute to its action. Sucralfate, with its strong negative charge, binds to exposed positively-charged proteins at the base of ulcers. In this way, it coats the ulcer and forms a physical barrier that protects the ulcer surface from further in...
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Absorption: Minimally absorbed from the gastrointestinal tract (up to 5% of the disaccharide component and less than 0.02% of aluminum).
Route of elimination: The small amounts of the sulfated disaccharide that are absorbed are excreted primarily in the urine.
Half Life: Not known.
Toxicity: Acute oral toxicity (LD50) in mice is >8000 mg/kg. There is limited experience in humans with overdosage of sucralfate. Sucralfate is only minimally absorbed from the gastrointestinal tract and thus risks associated with acute overdosage should be minimal. In rare reports describing sucralfate overdose, most patients remained asymptomatic.
Affected organisms: Humans and other mammals
Food interaction:
Avoid alcohol.
Take on empty stomach: 1 hour before or 2 hours after meals.
Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.
Take with a full glass of water.
Drug interaction:
WarfarinSucralfate may reduce the absorption of warfarin. Warfarin should be administered at least 2 hours before or 6 hours after sucralfate administration. Monitor for changes in prothrombin time if sucralfate is initiated, discontinued or dose changed.
PhenytoinSucralfate decreases the effect of hydantoin
ClodronateFormation of non-absorbable complexes
ItraconazoleSucralfate may decrease the absorption of itraconazole.
FosphenytoinSucralfate decreases the effect of hydantoin
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