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QuickView for Temazepam (compound)


PubChem
Name: Temazepam
PubChem Compound ID: 5391
Description: A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.
Molecular formula: C16H13ClN2O2
Molecular weight: 300.739 g/mol
Synonyms:
BRN 0759300; Planum; Ro 5-5345; NSC246303; 846-50-4; NSC 246303; Oxydiazepam; DEA No. 2925; temazep von ct; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-.
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DrugBank
Identification
Name: Temazepam
Name (isomeric): DB00231
Drug Type: small molecule
Description: A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.
Synonyms:
Hydroxydiazepam; N-Methyloxazepam; Methyloxazepam; Oxydiazepam
Brand: Levanxene, Normison, Remestan, Temaz, Signopam, Apo-Temazepam, Gelthix, Crisonar, Cerepax, Euhypnos, Euipnos, Mabertin, Restoril, Planum, Novo-Temazepam, Perdorm, Levanxol, Levanzene
Category: Adjuvants, Anesthesia, Benzodiazepines, Anti-anxiety Agents, GABA Modulators, Hypnotics and Sedatives
CAS number: 846-50-4
Pharmacology
Indication: For the short-term treatment of insomnia (generally 7-10 days).
Pharmacology:
Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors. Results are sedation, hypn...
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Mechanism of Action:
Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA recept...
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Absorption: Well absorbed, minimal first-pass metabolism.
Protein binding: 96%
Biotransformation: Hepatic. Temazepam is completely metabolized through conjugation prior to excretion. The major metabolite is the O-conjugate of temazepam (90%).
Route of elimination: Temazepam was completely metabolized through conjugation prior to excretion; 80% to 90% of the dose appeared in the urine.
Half Life: 10-20 hours
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid avocado.
Avoid alcohol.
Avoid excessive quantities of coffee or tea (Caffeine).
Drug interaction:
TheophyllineTheophylline may decrease the efficacy of Temazepam. Monitor for changes in the therapeutic effect of Temazepam if Theophylline is initiated, discontinued or dose changed.
TriprolidineThe CNS depressants, Triprolidine and Temazepam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
AminophyllineAminophylline may decrease the efficacy of Temazepam. Monitor for changes in the therapeutic effect of Temazepam if Aminophylline is initiated, discontinued or dose changed.
ClozapineThe benzodiazepine, Temazepam, may increase the adverse effects of Clozapine. Monitor for respiratory depression and hypotension if concomitant therapy is initiated.
DyphyllineDyphylline may decrease the efficacy of Temazepam. Monitor for changes in the therapeutic effect of Temazepam if Dyphylline is initiated, discontinued or dose changed.
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Enzymes