Name: | Temazepam |
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PubChem Compound ID: | 5391 |
Description: | A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent. |
Molecular formula: | C16H13ClN2O2 |
Molecular weight: | 300.739 g/mol |
Synonyms: |
BRN 0759300; Planum; Ro 5-5345; NSC246303; 846-50-4; NSC 246303; Oxydiazepam; DEA No. 2925; temazep von ct; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-.
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Name: | Temazepam |
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Name (isomeric): | DB00231 |
Drug Type: | small molecule |
Description: | A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent. |
Synonyms: |
Hydroxydiazepam; N-Methyloxazepam; Methyloxazepam; Oxydiazepam
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Brand: | Levanxene, Normison, Remestan, Temaz, Signopam, Apo-Temazepam, Gelthix, Crisonar, Cerepax, Euhypnos, Euipnos, Mabertin, Restoril, Planum, Novo-Temazepam, Perdorm, Levanxol, Levanzene |
Category: | Adjuvants, Anesthesia, Benzodiazepines, Anti-anxiety Agents, GABA Modulators, Hypnotics and Sedatives |
CAS number: | 846-50-4 |
Indication: | For the short-term treatment of insomnia (generally 7-10 days). |
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Pharmacology: |
Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors. Results are sedation, hypn...
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Mechanism of Action: |
Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA recept...
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Absorption: | Well absorbed, minimal first-pass metabolism. |
Protein binding: | 96% |
Biotransformation: | Hepatic. Temazepam is completely metabolized through conjugation prior to excretion. The major metabolite is the O-conjugate of temazepam (90%). |
Route of elimination: | Temazepam was completely metabolized through conjugation prior to excretion; 80% to 90% of the dose appeared in the urine. |
Half Life: | 10-20 hours |
Affected organisms: | Humans and other mammals |
Food interaction: |
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Drug interaction: |
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