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QuickView for dopamine (compound)


PubChem
Name: Dopamine
PubChem Compound ID: 11506498
Description: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Molecular formula: C8H11NO2
Molecular weight: 159.203 g/mol
DrugBank
Identification
Name: Dopamine
Name (isomeric): DB00988
Drug Type: small molecule
Description: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Synonyms:
Oxytyramine; Deoxyepinephrine; Hydroxytyramine; Dophamine; Dopamine HCl; Hydroxytyramin; DA; Dopamin
Brand: Intropin, Revimine
Category: Sympathomimetic, Cardiotonic Agents, Sympathomimetics, Dopamine Agents
CAS number: 51-61-6
Pharmacology
Indication: For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure
Pharmacology:
Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positi...
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Mechanism of Action:
Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on ...
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Absorption: Dopamine is rapidly absorbed from the small intestine.
Protein binding: No information currently available on protein binding.
Biotransformation: Biotransformation of dopamine proceeds rapidly to yield the principal excretion products, 3-4-dihydroxy-phenylacetic acid (DOPAC) and 3-methoxy-4-hydroxy-phenylacetic acid (homovanillic acid, HVA).
Route of elimination: It has been reported that about 80% of the drug is excreted in the urine within 24 hours, primarily as HVA and its sulfate and glucuronide conjugates and as 3,4-dihydroxyphenylacetic acid. A very small portion is excreted unchanged.
Half Life: 2 minutes
Toxicity: LD50 oral mice = 1460 mg/kg, LD50 oral rats = 1780 mg/kg. Spasm or closing of eyelids, nausea, vomiting, cardiac arrhythmias, involuntary movements of the body including the face, tongue, arms, hand, head, and upper body; hypotension, haemolytic anaemia, urinary retention, duodenal ulcer, sialorrhea, ataxia, abdominal pain, dry mouth, nightmares, tachypnoea, bruxism, confusion, and insomnia.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
DesipramineThe tricyclic antidepressant, desipramine, increases the sympathomimetic effect of dopamine.
PhenelzineIncreased arterial pressure
IsocarboxazidIncreased arterial pressure
PhenytoinRisk of severe hypotension
ReserpineIncreased arterial pressure
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