QuickView for Hexobarbital (compound)

Summary
General Info

PubChem

PubChem Compound 10464307

Name:	Hexobarbital
PubChem Compound ID:	10464307
Description:	A barbiturate that is effective as a hypnotic and sedative.
Molecular formula:	C₆H₁₀O
Molecular weight:	101.161 g/mol

DrugBank

Identification

Name:	Hexobarbital
Name (isomeric):	DB01355
Drug Type:	small molecule
Description:	A barbiturate that is effective as a hypnotic and sedative.
Synonyms:	Methexenyl; 5-(1-cyclohexen-1-yl)-1,5-dimethylbarbituric acid; Hexobarbitone; Methylhexabital
Brand:	Evipan, Cyclopal, Citopan, Sombulex, Barbidorm, Evipal, Cyclopan, Somnalert, Sombucaps, Noctivane
Category:	GABA Modulators, Hypnotics and Sedatives, Barbiturates, Adjuvants
CAS number:	56-29-1

Pharmacology

Indication:	For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli.
Pharmacology:	Hexobarbital is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s-1950s as an agent for inducing anesthesia for surgery and has a relatively fast onset of effects and short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it... show more » Hexobarbital is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s-1950s as an agent for inducing anesthesia for surgery and has a relatively fast onset of effects and short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine, usually thiopental would be the barbiturate of choice for this application these days. show less «
Mechanism of Action:	Hexobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Protein binding:	25%
Biotransformation:	Hepatic.
Toxicity:	Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
Affected organisms:	Humans and other mammals

Interactions

Drug interaction:

Dexamethasone	The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, dexamethasone.
Theophylline	The barbiturate, hexobarbital, decreases the effect of theophylline.
Ethinyl Estradiol	This product may cause a slight decrease of contraceptive effect
Clomifene	The enzyme inducer, hexobarbital, decreases the effect of the hormone agent, clomifene.
Fludrocortisone	The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, fludrocortisone.

Dexamethasone	The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, dexamethasone.
Theophylline	The barbiturate, hexobarbital, decreases the effect of theophylline.
Ethinyl Estradiol	This product may cause a slight decrease of contraceptive effect
Clomifene	The enzyme inducer, hexobarbital, decreases the effect of the hormone agent, clomifene.
Fludrocortisone	The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, fludrocortisone.
Doxycycline	The anticonvulsant, hexobarbital, decreases the effect of doxycycline.
Metronidazole	The barbiturate, hexobarbital, decreases the effect of metronidazole.
Oxtriphylline	The barbiturate, hexobarbital, decreases the effect of oxtriphylline.
Diethylstilbestrol	The enzyme inducer, hexobarbital, decreases the effect of the hormone agent, diethylstilbestrol.
Cyclosporine	The barbiturate, hexobarbital, increases the effect of cyclosporine.
Methadone	The barbiturate, hexobarbital, decreases the effect of methadone.
Estradiol	The enzyme inducer, hexobarbital, decreases the effect of the hormone agent, estradiol.
Betamethasone	The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, betamethasone.
Levonorgestrel	Phenobarbital decreases the effect of levonorgestrel
Nifedipine	The barbiturate, hexobarbital, decreases the effect of the calcium channel blocker, nifedipine.
Quinidine	The anticonvulsant, hexobarbital, decreases the effect of quinidine.
Prednisolone	The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, prednisolone.
Gefitinib	The CYP3A4 inducer, hexobarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Medroxyprogesterone	The enzyme inducer, hexobarbital, decreases the effect of the hormone agent, medroxyprogesterone.
Aminophylline	The barbiturate, hexobarbital, decreases the effect of aminophylline.
Norethindrone	This product may cause a slight decrease of contraceptive effect
Megestrol	The enzyme inducer, hexobarbital, decreases the effect of the hormone agent, megestrol.
Conjugated Estrogens	The enzyme inducer, hexobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Folic Acid	Folic acid decreases the effect of anticonvulsant, hexobarbital.
Hydrocortisone	The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Felodipine	The barbiturate, hexobarbital, decreases the effect of felodipine.
Prednisone	The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, prednisone.
Divalproex sodium	Divalproex sodium increases the effect of the barbiturate, hexobarbital.
Triamcinolone	The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, triamcinolone.
Griseofulvin	The barbiturate, hexobarbital, decreases the effect of griseofulvin.