QuickView for Aprobarbital (compound)

2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylethyl)-5-(2-propenyl)- (9CI); 5-Allyl-5-isopropylbarbituric acid sodium salt; Aprobarbital sodium; 125-88-2; Aprobarbital; Isonal (swedish); Sodium 5-allyl-5-isopropylbarbiturate; Alurate elixir verdum; Alurate; Isonal.
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2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylethyl)-5-(2-propenyl)- (9CI); 5-Allyl-5-isopropylbarbituric acid sodium salt; Aprobarbital sodium; 125-88-2; Aprobarbital; Isonal (swedish); Sodium 5-allyl-5-isopropylbarbiturate; Alurate elixir verdum; Alurate; Isonal; Barbituric acid, 5-allyl-5-isopropyl-; BRN 0180858; Numal; 2,4,6 (1H,3H,5H)-Pyrimidinetrione, 5-(1-methylethyl)-5-(2-propenyl)-; 5-(propan-2-yl)-5-(prop-2-en-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione; 77-02-1; Allypropymalum; 5-24-09-00224 (Beilstein Handbook Reference); 2,4,6 (1H,3H,5H)-Pyrimidinetrione, 5-(1-methylethyl)-5-(2-propenyl)-, monosodium salt; C07826; 5-(1-Methylethyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; Allylisopropylmalonylurea; Isopral; Butalbital sodium; Barbituric acid, 5-allyl-5-isopropyl-, sodium salt; Allonal; CHEBI:2791; EINECS 200-997-4; Aprobarbitone; 5-allyl-5-isopropylpyrimidine-2,4,6(1H,3H,5H)-trione; Aprobarbitalum [INN-Latin]; Isopropylallylbarbituric acid; DEA No. 2100; Aprobarbital [DCF:INN]; Somnipron; Allional; Alurate (TN); Sodium aprobarbital; HSDB 3290; Alurate Sodium; Barital; Barbituric acid, 5-allyl-5-isopropyl-, sodium deriv; D00698; NSC120767; NSC 120769; Aprobarbita; Aprozal; NSC120769; Aprotal; Arbatal; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylethyl)-5-(2-propenyl)-; Allylisopropylbarbituric acid; Alubarb; Allylpropymal; 5-Allyl-5-isopropylbarbituric acid; 5-Isopropyl-5-allylbarbituric acid; Aprobarbitale [DCIT]; CCRIS 7088; Allypropymal; 5-Allyl-5-isopropylbarbiturate
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Aprobarbital (like all barbiturates) works by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding sites that are distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. This GABAA receptor binding decr...
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Aprobarbital (like all barbiturates) works by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding sites that are distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. This GABAA receptor binding decreases input resistance, depresses burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increases both the amplitude and decay time of inhibitory postsynaptic currents. In addition to this GABA-ergic effect, barbiturates also block the AMPA receptor, a subtype of glutamate receptor. Glutamate is the principal excitatory neurotransmitter in the mammalian CNS. Aprobarbital also appears to bind neuronal nicotinic acetylcholine receptors.
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