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QuickView for Norethindrone (compound)


PubChem
Name: Norethindrone
PubChem Compound ID: 11865443
Description: A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
Molecular formula: C20H26O2
Molecular weight: 298.419 g/mol
Synonyms:
ZINC03831215
DrugBank
Identification
Name: Norethindrone
Name (isomeric): DB00717
Drug Type: small molecule
Description: A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
Brand: Utovlan, Orlest, Utovlar, Noraethisteronum, Brevinor-1 21, Menzol, Ciclovulan, Primolut N, Brevinor-1 28, Norluten, ENT, Norimin, Loestrin 24 Fe, Trinovum 21, Ortho-Novum 1 50, Ortho 7 7 7, Conludaf, Conludag, Errin, Norethynodrone, Microneth, Anovulatorio, Palonyl, Estrinor, Micronett, Necon, Anhydrohydroxynorprogesterone, Norethin, Aygestin, Norpregneninlone, Binovum, Genora, Noresthisterone, Anovule, Noretisterone [Dcit], Loestrin, Ethynylmortestosterone, Norcolut, Norethindrone Norethisterone, Normapause, Norcept-E, Noriday, Nor-Qd, Noretisterona [INN-Spanish], Noriday 28, Norethisterone [Progestins], Ortho-Novum 1 35, Proluteasi, Norethyndron, Ortho 1 35, Norgestin, Conceplan, Nodiol, Jenest-28, Ovysmen, Tri-Norinyl, Minovlar, Micronor, Norlutate, Nelova, Norethynodron, Norpregneninolone, Demulen, Norethisteronum [INN-Latin], Triella, Norethindrone Acetate, Synphase, Ovysmen 0.5 35, Nor-Q.D., Norlutin, Gencept, Ovysmen 1 35, Synphasic 28, Norethisterone, Perovex, Gestest, Brevinor, Norethisteron, Ethynylnortestosterone, Trinovum, Mini-Pe, Ortho-Novum, Brevinor 21, Norlestrin, Brevinor 28, Neocon, Modicon, Jenest, Norfor, Milli, Primolut-N, Norethin 1/35 E, N.E.E., Brevicon, Norluton, Noralutin, NET, Micronovum, Camila, Ortho-Novum 7 7 7, Norinyl, Ethinylnortestosterone, Norpregneninotone, Mini-Pill, Norethadrone, Norcept, Norethin 1/50 M, Ovcon
Brand name mixture:
Estalis 250/50 Mcg(Estradiol + Norethindrone Acetate), Norinyl 1/50 (28 day)(Mestranol + Norethindrone), Synphasic (28 day)(Ethinyl Estradiol + Norethindrone), Brevicon 0.5/35 Tablets (28 day)(Ethinyl Estradiol + Norethindrone), Minestrin 1/20 28(Ethinyl Estradiol + Norethindrone Acetate), Brevicon 0.5/35 (21 day)(Ethinyl Estradiol + Norethindro...
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Category: Progestins, Contraceptives, Oral, Synthetic
CAS number: 68-22-4
Pharmacology
Indication: For use as an oral contraceptive in the prevention of pregnancy.
Pharmacology: Norethindrone is a synthetic oral progestin. It is used for contraception or to treat such conditions as secondary amenorrhea, abnormal uterine bleeding, and endometriosis. As an oral contraceptive, norethindrone is available as either a single agent or in combination with an estrogen.
Mechanism of Action:
Progestins diffuse freely into target cells and bind to the progesterone receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory...
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Absorption: Absolute oral bioavailability approximately 64%
Protein binding: >95%
Biotransformation: Hepatic
Half Life: 7 hours
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take without regard to meals.
Drug interaction:
CarbamazepineThis product may cause a slight decrease of contraceptive effect
TretinoinOral Tretinoin may decrease the effect of oral contraceptive, Norethindrone. An alternate form of contraception should be used during concomitant therapy.
TalbutalThis product may cause a slight decrease of contraceptive effect
St. John's WortSt. John's Wort could reduce the contraceptive effect
RifabutinRifabutin may decrease the contraceptive effect of norethindrone. Hormonal contraception should not be solely relied on alone during concomitant therapy with rifabutin.
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