Bookmark
Forward
QuickView for Penbutolol (compound)
PubChem
| Name: | Penbutolol |
|---|---|
| PubChem Compound ID: | 190541 |
| Description: | A nonselective beta-blocker used as an antihypertensive and an antianginal agent. |
| Molecular formula: | C36H60N2O8S |
| Molecular weight: | 680.936 g/mol |
| Synonyms: |
103437-28-1
|
DrugBank
Identification
| Name: | Penbutolol |
|---|---|
| Name (isomeric): | DB01359 |
| Drug Type: | small molecule |
| Description: | A nonselective beta-blocker used as an antihypertensive and an antianginal agent. |
| Synonyms: |
Penbutolol sulfate
|
| Brand: | Levatolol, Paginol, Betapressin, Levatol, Lobeta |
| Category: | Adrenergic beta-Antagonists, Antihypertensive Agents |
| CAS number: | 36507-48-9 |
Pharmacology
| Indication: | Used in the treatment of high blood pressure. |
|---|---|
| Pharmacology: | Penbutolol is a non-selective beta blocker. Beta-blockers work by affecting the response to some nerve impulses in certain parts of the body. As a result, they decrease the heart's need for blood and oxygen by reducing its workload. They also help the heart to beat more regularly. |
| Mechanism of Action: |
Penbutolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle and beta(2)-receptors in the bronchial and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both ...
show more » |
| Absorption: | Oral bioavailability is 90%. |
| Protein binding: | 80-98% bound to plasma proteins. |
| Biotransformation: | Metabolized in the liver by hydroxylation and glucuroconjugation forming a glucuronide metabolite and a semi-active 4-hydroxy metabolite. |
| Route of elimination: | The metabolites are excreted principally in the urine. |
| Half Life: | Phase 1: 2.5 hours; phase 2: 24 hours |
| Toxicity: | Symptoms of overdose include drowsiness, vertigo, headache, and atriventricular block. |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
|
|---|
Targets
Carriers
