QuickView for Oxtriphylline (compound)

Summary
General Info

PubChem

PubChem Compound 20585

Name:	cholinophyllin
PubChem Compound ID:	20585
Molecular formula:	C₁₂H₂₂N₅O₃⁺
Molecular weight:	284.335 g/mol
Synonyms:	Colina teofillinato [DCIT]; Soliphylline; Theophylline cholinate; Oxtriphylline; 146-71-4; 4499-40-5; Theoxylline; 13930-27-3; Brondecon; Cholegyl. show more » Colina teofillinato [DCIT]; Soliphylline; Theophylline cholinate; Oxtriphylline; 146-71-4; 4499-40-5; Theoxylline; 13930-27-3; Brondecon; Cholegyl; Choledyl; Teokolin; (2-Hydroxyethyl)trimethylammonium compound with theophylline; Choline theophyllinate; Theophylline salt of choline; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, ion(1-), 2-hydroxy-N,N,N-trimethylethanaminium; Choline, hydroxide, compd. with theophylline (1:1); Teofilinato de colina [INN-Spanish]; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:1); Cholinophyllin; Theophylline, compd. with choline; 56553-57-2; Zy 15061; Choline salt with theophylline (1:1); Choline theophylline salt; Choline, compd. with theophylline (1:1); Theophyllinate de choline [INN-French]; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 3,7-dihydro-1,3-dimethylpurine-2,6-dione; Oxtriphylline [USAN]; Filoral; EINECS 224-798-7; Choledyl SA 400; Cholini theophyllinas [INN-Latin]; Sabidal; Teofilcolina; Cholinophylline; Oxtrimethylline show less «

DrugBank

Identification

Name:	cholinophyllin
Name (isomeric):	DB01303
Drug Type:	small molecule
Synonyms:	Choline theophylline
Brand:	Theocolin, Choledyl
Category:	Bronchodilator Agents
CAS number:	4499-40-5

Pharmacology

Indication:	Used to treat the symptoms of asthma, bronchitis, and emphysema.
Pharmacology:	Oxtriphylline is a bronchodilator. Oxtriphylline works in several ways: it relaxes muscles in your lungs and chest to allow more air in, decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and increases the contractions of your diaphragm to draw more air into the lungs.
Mechanism of Action:	Oxtriphylline is a choline salt of theophylline. Oxtriphylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Oxtriphylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking d... show more » Oxtriphylline is a choline salt of theophylline. Oxtriphylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Oxtriphylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Oxtriphylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction. show less «
Toxicity:	Symptoms of toxicity include abdominal pain (continuing or severe), confusion or change in behavior, convulsions (seizures), dark or bloody vomit, diarrhea, dizziness or lightheadedness, fast and/or irregular heartbeat, nervousness or restlessness (continuing), and trembling (continuing).
Affected organisms:	Humans and other mammals

Interactions

Food interaction:

Take with food to reduce irritation.

Avoid high doses of caffeine.

Drug interaction:

Mestranol	The contraceptive increases the effect and toxicity of theophylline
Vecuronium	Theophylline decreases the effect of muscle relaxant
Erythromycin	The macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.
Atracurium	Theophylline decreases the effect of muscle relaxant
Propranolol	Antagonism of action and increased effect of theophylline

Mestranol	The contraceptive increases the effect and toxicity of theophylline
Vecuronium	Theophylline decreases the effect of muscle relaxant
Erythromycin	The macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.
Atracurium	Theophylline decreases the effect of muscle relaxant
Propranolol	Antagonism of action and increased effect of theophylline
Pentobarbital	The barbiturate, pentobarbital, decreases the effect of oxtriphylline.
Secobarbital	The barbiturate, secobarbital, decreases the effect of oxtriphylline.
Tubocurarine	Theophylline decreases the effect of muscle relaxant
Primidone	The barbiturate, primidone, decreases the effect of oxtriphylline.
Butethal	The barbiturate, butethal, decreases the effect of oxtriphylline.
Peginterferon alfa-2a	Interferon increases the effect and toxicity of theophylline
Ciprofloxacin	Ciprofloxacin may increase the effect of oxtriphylline.
Metocurine	Theophylline decreases the effect of muscle relaxant
Sotalol	Antagonism of action and increased effect of theophylline
Thiabendazole	Thiabendazole increases the effect and toxicity of theophylline
Propafenone	Propafenone increases the effect of theophylline
Lithium	Theophylline decreases serum levels of lithium
Enoxacin	Enoxacin may increase the effect of oxtriphylline.
Aprobarbital	The barbiturate, aprobarbital, decreases the effect of oxtriphylline.
Tacrine	Tacrine increases the effect and toxicity of theophylline
Aciclovir	Aciclovir may increase the effect and toxicity of oxtriphylline.
Pefloxacin	Pefloxacin may increase the effect of oxtriphylline.
Carteolol	Antagonism of action and increased effect of theophylline
Ritonavir	Ritonavir decreases the effect of theophylline
Halothane	Increased risk of cardiac arrhythmia
Talbutal	The barbiturate, talbutal, decreases the effect of oxtriphylline.
Mivacurium	Theophylline decreases the effect of muscle relaxant
Zileuton	Zileuton increases the effect and toxicity of theophylline
Amobarbital	The barbiturate, amobarbital, decreases the effect of oxtriphylline.
Isoniazid	Isoniazid may increase the effect and toxicity of oxtriphylline.
Pentoxifylline	Pentoxifylline increases the effect and toxicity of theophylline
Peginterferon alfa-2b	Interferon increases the effect and toxicity of theophylline
Josamycin	The macrolide, josamycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.
Ethinyl Estradiol	The contraceptive increases the effect and toxicity of theophylline
Nadolol	Antagonism of action and increased effect of theophylline
Dihydroquinidine barbiturate	The barbiturate, dihydroquinidine barbiturate, decreases the effect of oxtriphylline.
Mexiletine	Mexiletine increases the effect and toxicity of theophylline
Phenytoin	Decreased effect of both products
Phenobarbital	The barbiturate, phenobarbital, decreases the effect of oxtriphylline.
Disulfiram	Disulfiram may increase the effect and toxicity of oxtriphylline.
Carbamazepine	Carbamazepine may decrease the serum concentration of oxtriphylline. Oxtriphylline may decrease the serum concentration of carbamazepine. Monitor for changes in the therapeutic effect of both agents if concomitant therapy is initiated, discontinued or dose changed.
Pancuronium	Theophylline decreases the effect of muscle relaxant
Interferon alfa-n1	Interferon increases the effect and toxicity of theophylline
Methylphenobarbital	The barbiturate, methylphenobarbital, decreases the effect of oxtriphylline.
Cimetidine	Cimetidine may increase the serum concentration of oxtriphylline by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of oxtriphylline if cimetidine is initiated, discontinued or dose changed.
Norfloxacin	Norfloxacin may increase the effect of oxtriphylline.
Clarithromycin	Clarithromycin may increase the effect and toxicity of oxtriphylline.
Methohexital	The barbiturate, methohexital, decreases the effect of oxtriphylline.
Butabarbital	The barbiturate, butabarbital, decreases the effect of oxtriphylline.
Ethotoin	Decreased effect of both products
Doxacurium chloride	Theophylline decreases the effect of muscle relaxant
Interferon Alfa-2a, Recombinant	Interferon increases the effect and toxicity of theophylline
Terbinafine	Terbinafine increases the effect and toxicity of theophylline
Heptabarbital	The barbiturate, heptabarbital, decreases the effect of oxtriphylline.
Butalbital	The barbiturate, butalbital, decreases the effect of oxtriphylline.
Timolol	Antagonism of action and increased effect of theophylline
Quinidine barbiturate	The barbiturate, quinidine barbiturate, decreases the effect of oxtriphylline.
Ticlopidine	Ticlopidine increases the effect and toxicity of theophylline
Fosphenytoin	Decreased effect of both products
Hexobarbital	The barbiturate, hexobarbital, decreases the effect of oxtriphylline.
Mephenytoin	Decreased effect of both products
Rofecoxib	Rofecoxib increases the effect and toxicity of theophylline
Rifampin	Rifampin may decrease the effect and toxicity of oxtriphylline.
Penbutolol	Antagonism of action and increased effect of theophylline
Troleandomycin	The macrolide, troleandomycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.
Pindolol	Antagonism of action and increased effect of theophylline
Grepafloxacin	Grepafloxacin may increase the effect of oxtriphylline.
Interferon Alfa-2b, Recombinant	Interferon increases the effect and toxicity of theophylline
Fluvoxamine	Fluvoxamine may increase the therapeutic and adverse effects of oxtriphylline.
Adenosine	This xanthine decreases the effect of adenosine
Verapamil	Verapamil increases the effect of theophylline
St. John's Wort	St. John's Wort decreases the effect of theophylline

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Targets

cGMP-inhibited 3',5'-cyclic phosphodiesterase A

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Adenosine A2a receptor

Adenosine A1 receptor

Enzymes

Cytochrome P450 1A2

Transporters

Solute carrier family 22 member 7