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QuickView for Propiomazine (compound)

Name: propiomazine
PubChem Compound ID: 4940
Molecular formula: C20H24N2OS
Molecular weight: 340.483 g/mol
Propiomazine; 362-29-8; 2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazine; Propiomazine [USAN:BAN:INN]; NINDS_000296; 1-Propanone, 1-(10-(2-(dimethylamino)propyl)phenothiazin-2-yl)-; Propiomazinum [INN-Latin]; Spectrum3_000559; Spectrum2_000930; KBio1_000296.
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Name: propiomazine
Name (isomeric): DB00777
Drug Type: small molecule
Brand: Largon, Propiomazina [INN-Spanish], Propiomazine [Usan:Ban:Inn], Propionylpromethazine, Propiomazinum [INN-Latin], Phenoctyl
Category: Sedatives and Hypnotics
CAS number: 362-29-8
Indication: Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia.
Pharmacology: Although propiomazine is a phenothiazine, it is not used as an antipsychotic. It posesses antihistamine effects and is mostly used as a sedative in treating insomnia.
Mechanism of Action: Propiomazine is an antagonist at types 1, 2, and 4 dopamine receptors, serotonin (5-HT) receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Its main use as a sedative is due to its antihistamine effect.
Protein binding: 81%
Biotransformation: Unknown, but most likely hepatic as with other phenothiazines.
Toxicity: Rare, serious side effects include convulsions (seizures); difficult or unusually fast breathing; fast or irregular heartbeat or pulse; fever (high); high or low blood pressure; loss of bladder control; muscle stiffness (severe); unusual increase in sweating; unusually pale skin; and unusual tiredness or weakness.
Affected organisms: Humans and other mammals
Drug interaction:
GrepafloxacinIncreased risk of cardiotoxicity and arrhythmias
LevofloxacinIncreased risk of cardiotoxicity and arrhythmias
TerfenadineIncreased risk of cardiotoxicity and arrhythmias
PhentermineDecreased anorexic effect, may increase psychotic symptoms
PhenylpropanolamineDecreased anorexic effect, may increase psychotic symptoms
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