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QuickView for Propiomazine (compound)
PubChem
| Name: | propiomazine |
|---|---|
| PubChem Compound ID: | 4940 |
| Molecular formula: | C20H24N2OS |
| Molecular weight: | 340.483 g/mol |
| Synonyms: |
Propiomazine; 362-29-8; 2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazine; Propiomazine [USAN:BAN:INN]; NINDS_000296; 1-Propanone, 1-(10-(2-(dimethylamino)propyl)phenothiazin-2-yl)-; Propiomazinum [INN-Latin]; Spectrum3_000559; Spectrum2_000930; KBio1_000296.
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DrugBank
Identification
| Name: | propiomazine |
|---|---|
| Name (isomeric): | DB00777 |
| Drug Type: | small molecule |
| Brand: | Largon, Propiomazina [INN-Spanish], Propiomazine [Usan:Ban:Inn], Propionylpromethazine, Propiomazinum [INN-Latin], Phenoctyl |
| Category: | Sedatives and Hypnotics |
| CAS number: | 362-29-8 |
Pharmacology
| Indication: | Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. |
|---|---|
| Pharmacology: | Although propiomazine is a phenothiazine, it is not used as an antipsychotic. It posesses antihistamine effects and is mostly used as a sedative in treating insomnia. |
| Mechanism of Action: | Propiomazine is an antagonist at types 1, 2, and 4 dopamine receptors, serotonin (5-HT) receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Its main use as a sedative is due to its antihistamine effect. |
| Protein binding: | 81% |
| Biotransformation: | Unknown, but most likely hepatic as with other phenothiazines. |
| Toxicity: | Rare, serious side effects include convulsions (seizures); difficult or unusually fast breathing; fast or irregular heartbeat or pulse; fever (high); high or low blood pressure; loss of bladder control; muscle stiffness (severe); unusual increase in sweating; unusually pale skin; and unusual tiredness or weakness. |
| Affected organisms: | Humans and other mammals |
Interactions
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Targets
