Name: | Promazine |
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PubChem Compound ID: | 10850726 |
Description: | A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. |
Molecular formula: | C17H20N2S |
Molecular weight: | 285.413 g/mol |
Name: | Promazine |
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Name (isomeric): | DB00420 |
Drug Type: | small molecule |
Description: | A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. |
Synonyms: |
Promazin; Chlorpromazine Hcl; Promazine Hcl; CPZ; Promazina; Phenothiazine
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Brand: | Promapar, Promwill, Largactyl, Sparine, Liranol, Chlorpromazine Hcl Intensol, Promazil, Chlor-Promanyl, Thorazine, Largactil, Sanopron, Phenactyl, Prazin, Romtiazin, Ampliactil, Novomazina, Chlorderazin, Megaphen, AB, Verophen, Aminazine, Prazine, Psychozine, Protactyl, Ampazine, Elmarin, Propaphenin, Sonazine, Fraction, Aminazin, Fenaktyl, Proma, Neo-Hibernex, Promactil, Berophen, Chlordelazin, Wintermin, Fenactil, Sinophenin, Vesprin, Esparin, Amplictil, Torazina, Esmind, Contomin, Chlorpromados, Chlropromados, Prozil, Largactilothiazine |
Category: | Phenothiazines, Neuroleptics, Antiemetics, Dopamine Antagonists, Antipsychotic Agents, Antipsychotics |
CAS number: | 58-40-2 |
Indication: | Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly. |
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Pharmacology: |
Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. T...
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Mechanism of Action: |
Promazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Promazine's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine typ...
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Absorption: | Absorption may be erratic and peak plasma concentrations show large interindividual differences. |
Protein binding: | 94% |
Biotransformation: | Hepatic, primarily to N-desmethylpromazine and promazine sulfoxide. |
Toxicity: | Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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