Name: | Nadolol |
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PubChem Compound ID: | 11255327 |
Description: | A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for MIGRAINE DISORDERS and for tremor. |
Molecular formula: | C17H27NO4 |
Molecular weight: | 309.401 g/mol |
Name: | Nadolol |
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Name (isomeric): | DB01203 |
Drug Type: | small molecule |
Description: | A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for MIGRAINE DISORDERS and for tremor. |
Brand: | Corgard, Anabet, Solgol |
Brand name mixture: | Corzide Tab W Nadolol 40mg(Bendroflumethiazide + Nadolol), Corzide Tab W Nadolol 80mg(Bendroflumethiazide + Nadolol) |
Category: | Sympatholytics, Adrenergic beta-Antagonists, Anti-Arrhythmia Agents, Antihypertensive Agents |
CAS number: | 42200-33-9 |
Indication: | Used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. |
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Pharmacology: |
Nadolol is a nonselective beta-adrenergic receptor antagonist with a long half-life, and is structurally similar to propranolol. Clinical pharmacology studies have demonstrated beta-blocking activity by showing (1) reduction in heart rate and cardiac output at rest and on exercise, (2) reduction of systolic and diastolic blood pressure at rest and ...
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Mechanism of Action: |
Like other beta-adrenergic antagonists, nadolol competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. Like propranolol and timolol, nadolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects of the catecholamines epinephrine and norepinephrine ...
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Absorption: | Absorption of nadolol after oral dosing is variable, averaging about 30 percent. |
Protein binding: | 30% |
Biotransformation: | Not metabolized by the liver and excreted unchanged primarily by the kidneys. |
Route of elimination: | Unlike many other beta-adrenergic blocking agents, nadolol is not metabolized by the liver and is excreted unchanged, principally by the kidneys. Nadolol is excreted predominantly in the urine. |
Half Life: | 14-24 hours |
Toxicity: | Oral, mouse: LD50 = 4500mg/kg. Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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Drug interaction: |
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