Name: | Metoprolol |
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PubChem Compound ID: | 11957594 |
Description: | A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS. |
Molecular formula: | C34H56N2O12 |
Molecular weight: | 684.815 g/mol |
Synonyms: |
EU-0100728
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Name: | Metoprolol |
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Name (isomeric): | DB00264 |
Drug Type: | small molecule |
Description: | A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS. |
Synonyms: |
Metoprolol succinate; Metoprolol Tartrate
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Brand: | Lopresor, Lopressor HCT, Lopressor, Prelis, Metroprolol, Selo-Zok, Toprol-XL, Selopral, Beloc, Betaloc, Lopresoretic, Toprol XL, Seloken, Toprol |
Category: | Sympatholytics, Adrenergic Agents, Antiarrhythmic Agents, Adrenergic beta-Antagonists, Anti-Arrhythmia Agents, Antihypertensive Agents |
CAS number: | 37350-58-6 |
Indication: | For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches. |
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Pharmacology: | Metoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA). |
Mechanism of Action: | Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure. |
Absorption: | Rapid and complete, 50% |
Protein binding: | 12% |
Biotransformation: | Primarily hepatic |
Route of elimination: | Less than 5% of an oral dose of metoprolol is recovered unchanged in the urine; the rest is excreted by the kidneys as metabolites that appear to have no beta-blocking activity. |
Half Life: | 3-7 hours |
Toxicity: | LD50=5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD50=2090 mg/kg (orally in mice) |
Affected organisms: | Humans and other mammals |
Food interaction: |
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