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QuickView for Haloperidol (compound)


PubChem
Name: Haloperidol
PubChem Compound ID: 11495267
Description: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
Molecular formula: C21H24Cl2FNO2
Molecular weight: 412.325 g/mol
DrugBank
Identification
Name: Haloperidol
Name (isomeric): DB00502
Drug Type: small molecule
Description: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
Brand: Eukystol, Brotopon, Serenase, Pms Haloperidol, Pekuces, Sernas, Serenelfi, Haldol La, Haldol Solutab, Sigaperidol, Mixidol, Haldol, Peridol, Halidol, Aloperidolo, Apo-Haloperidol, Lealgin Compositum, Haloperidol Decanoate, Halopoidol, Vesalium, Halosten, Keselan, Einalon S, Aloperidol, Aloperidon, Peluces, Novo-Peridol, Haloperidol Lactate, Pernox, Aloperidin, Halol, Sernel, Uliolind, Dozic, Galoperidol, Halopidol, Ulcolind, Haldol Decanoate, Bioperidolo, Linton, Haloperido, Serenace, Dozix, ALDO, Haloperidol Intensol, Halojust, Halopal
Category: Antidyskinetics, Anti-Dyskinesia Agents, Antiemetics, Dopamine Antagonists, Antipsychotic Agents, Antipsychotics, Butyrophenones
CAS number: 52-86-8
Pharmacology
Indication: For the management of psychotic disorders (eg. schizophrenia) and delirium, as well as to control tics and vocal utterances of Tourette's syndrome (Gilles de la Tourette's syndrome). Also used for the treatment of severe behavioural problems in children with disrubtive behaviour disorder or ADHD (attention-deficit hyperactivity disorder). Haloperidol has been used in the prevention and control of severe nausea and vomiting.
Pharmacology:
Haloperidol is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Haloperidol principal pharmacological effects are similar to those of piperazine-derivative phenothiazines. The drug has action at all levels of the central nervous system-primarily at subcortical levels-as well as on m...
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Mechanism of Action:
The precise mechanism whereby the therapeutic effects of haloperidol are produced is not known, but the drug appears to depress the CNS at the subcortical level of the brain, midbrain, and brain stem reticular formation. Haloperidol seems to inhibit the ascending reticular activating system of the brain stem (possibly through the caudate nucleus), ...
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Absorption: Oral-60%
Protein binding: 92%
Biotransformation: Hepatic
Half Life: 3 weeks
Toxicity: LD50=165 mg/kg (rats, oral)
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take with food to reduce irritation, limit caffeine intake. Avoid alcohol.
Drug interaction:
LithiumPossible extrapyramidal effects and neurotoxicity with this combination
TolterodineHaloperidol may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
TamoxifenHaloperidol may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
GuanethidineHaloperidol may decrease the effect of guanethidine.
CarbamazepineCarbamazepine may decrease the serum concentration of haloperidol by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of haloperidol if carbamazepine is initiated, discontinued or dose changed.
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