Name: | Haloperidol |
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PubChem Compound ID: | 11495267 |
Description: | A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279) |
Molecular formula: | C21H24Cl2FNO2 |
Molecular weight: | 412.325 g/mol |
Name: | Haloperidol |
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Name (isomeric): | DB00502 |
Drug Type: | small molecule |
Description: | A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279) |
Brand: | Eukystol, Brotopon, Serenase, Pms Haloperidol, Pekuces, Sernas, Serenelfi, Haldol La, Haldol Solutab, Sigaperidol, Mixidol, Haldol, Peridol, Halidol, Aloperidolo, Apo-Haloperidol, Lealgin Compositum, Haloperidol Decanoate, Halopoidol, Vesalium, Halosten, Keselan, Einalon S, Aloperidol, Aloperidon, Peluces, Novo-Peridol, Haloperidol Lactate, Pernox, Aloperidin, Halol, Sernel, Uliolind, Dozic, Galoperidol, Halopidol, Ulcolind, Haldol Decanoate, Bioperidolo, Linton, Haloperido, Serenace, Dozix, ALDO, Haloperidol Intensol, Halojust, Halopal |
Category: | Antidyskinetics, Anti-Dyskinesia Agents, Antiemetics, Dopamine Antagonists, Antipsychotic Agents, Antipsychotics, Butyrophenones |
CAS number: | 52-86-8 |
Indication: | For the management of psychotic disorders (eg. schizophrenia) and delirium, as well as to control tics and vocal utterances of Tourette's syndrome (Gilles de la Tourette's syndrome). Also used for the treatment of severe behavioural problems in children with disrubtive behaviour disorder or ADHD (attention-deficit hyperactivity disorder). Haloperidol has been used in the prevention and control of severe nausea and vomiting. |
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Pharmacology: |
Haloperidol is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Haloperidol principal pharmacological effects are similar to those of piperazine-derivative phenothiazines. The drug has action at all levels of the central nervous system-primarily at subcortical levels-as well as on m...
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Mechanism of Action: |
The precise mechanism whereby the therapeutic effects of haloperidol are produced is not known, but the drug appears to depress the CNS at the subcortical level of the brain, midbrain, and brain stem reticular formation. Haloperidol seems to inhibit the ascending reticular activating system of the brain stem (possibly through the caudate nucleus), ...
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Absorption: | Oral-60% |
Protein binding: | 92% |
Biotransformation: | Hepatic |
Half Life: | 3 weeks |
Toxicity: | LD50=165 mg/kg (rats, oral) |
Affected organisms: | Humans and other mammals |
Food interaction: |
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